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Iranian Heart Journal، جلد ۱۹، شماره ۱، صفحات ۳۷-۴۳

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عنوان انگلیسی Comparing the Efficacy of 6% Hydroxyethyl Starch 130/0.4 and Human Albumin for Intravenous Fluid Replacement in Pediatric Open-Heart Surgery
چکیده انگلیسی مقاله Background: Providing and maintaining normovolemic condition during major surgeries is a majorchallenge, especially in children. In this respect, third-generation hydroxyethyl starches seem tobe more cost-effective than human albumin. However, the efficacy of 6% hydroxyethyl starch(HES) 130/0.4 compared to other alternatives such as human albumin 5% remains uncertain inchildren.The present study aimed to assess the efficacy and safety of replacing human albumin 5% with6% HES 130/0.4 for volume replacement therapy in children undergoing selective open cardiacsurgery.Method: This randomized double-blinded clinical trial was performed on 59 children aged less than 2years and ASA I-III who were candidated for selective open-heart surgery and referred to achildren medical center in 2014. The patients were randomly assigned via the blockrandomization method to the case group (n = 30) receiving a solution of 6% HES 130/0.4 andthe control group (n = 29) receiving 5% human albumin.There were no between-group differences in hemodynamic parameters-including pulse rate,systolic and diastolic blood pressures, and mean blood pressure-at the time points of beforeanesthesia induction, before and after pump insertion, and 24 hours after surgery.Results: Comparisons of the laboratory indices indicated no differences between the 2 groups at thedifferent time points. The volume of packed cell and colloid fluids infused in the case andcontrol group was also similar.Conclusions: Compared to human albumin 5%, 6% HES 130/0.4 is a safe alternative to fluid supplyduring cardiac surgery among children.
کلیدواژه‌های انگلیسی مقاله Hydroxyethyl, Human albumin, Pediatric open-heart surgery

نویسندگان مقاله Mojgan Rahimi |
Department of Anesthesiology. Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran

Saida Eshraqi |
Tehran University of Medical Sciences, Tehran, IR Iran

Behrang Nooralishahi |
Department of Anesthesiology. Children's Medical Center, Tehran University of Medical Sciences, Tehran, IR Iran


نشانی اینترنتی http://journal.iha.org.ir/article_82804_d155dd2df3e5b4e697f87a8e0004ac40.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/162/article-162-1423883.pdf
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