این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Heart Journal، جلد ۱۳، شماره ۱، صفحات ۱۱-۱۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی NTERLEUKIN-18 (IL-18) AND ATHEROSCLEROSIS
چکیده انگلیسی مقاله Background- Atherosclerosis is a dynamic and progressive disease arising from the combination of endothelial dysfunction and inflammation. So, inflammatory mediators are important causative and progressive factors in atherosclerosis. Interleukin-18 (IL-18) is a pleiotropic cytokine which may have a key role in atherosclerosis, because the results of recent studies indicated that IL-18, either directly as a pro-inflammatory factor or indirectly as an interferon inducing factor, has central role in the inflammatory cascade. In present study, we evaluated the relation between blood concentration of IL-18 with atherosclerosis and its severity and also the relation of this cytokine with the other known risk factors of coronary artery disease (CAD). Methods - 138 patients, who underwent diagnostic cardiac catheterization and had the inclusion criteria for this study, were selected. In the beginning, a questionnaire containing personal information and medical history was completed for each of them and blood samples were collected 24 hours before catheterization. We measured blood level of IL-18 and CRP in all samples. The results of these tests and the angiography were entered in the questionnaire and then information was analyzed using regression analyzing, K2 and statistical T test. P values of< 0.05 were considered statistically significant. Results- By using the results of angiography, patients were divided in two groups. 1- Control group or normal coronary arteries (32 people) 2- Case group (106 people) or patients who were suffering from CAD. In second group, 6 patients (5.6%) had minimal CAD, 44 patients (41.5%) had single-vessel disease (SVD), 27 patients (25.4%) had 2VD and 29 patients (27.5%) had 3VD. In the laboratory tests, the mean IL-18 blood level in patients with CAD was 258.1 pgr/ml but in normal coronary arteries group it was 216.6 pgr/ml. The average blood level of IL-18 in patients who had minimal CAD was 235.5 pgr/ml, in SVD was 247.2 pgr/ml, in 2VD was 263.7 pgr/ml and in patients with 3VD was 274.1 pgr/ml. Also average CRP blood level in normal group was 8.9 mgr/L while in patients with CAD it was 20.4 mgr/L. Conclusion- The results of this study indicated that there was a direct and significant correlation between blood IL-18 level with existence (P< 0.001) and severity of CAD (P< 0.01) and IL-18 can be an independent predictor risk factor of atherosclerosis.
کلیدواژه‌های انگلیسی مقاله INFLAMMATION, ATHEROSCLEROSIS, INTERLEUKIN 18, CAD, CYTOKINE
نویسندگان مقاله Nozar Givtaj |
Rajaie cardiovascular, medical and research center - Tehran University of medical science, Tehran Iran

Hossein ali Bassiri |
Rajaie cardiovascular, medical and research center - Tehran University of medical science, Tehran Iran

Nader Givtaj |
Rajaie cardiovascular, medical and research center - Tehran University of medical science, Tehran Iran

Asghar Simin |
Rajaie cardiovascular, medical and research center - Tehran University of medical science, Tehran Iran

Feridoun Noohi |
Rajaie cardiovascular, medical and research center - Tehran University of medical science, Tehran Iran

نشانی اینترنتی http://journal.iha.org.ir/article_83202_36b481bc417d4069189d6c9529073d96.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/162/article-162-1423989.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات