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Iranian Heart Journal، جلد ۸، شماره ۲، صفحات ۴۴-۵۰
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عنوان انگلیسی EFFECT OF FOLIC ACID ON SERUM HOMOCYSTEINE AND MORBIDITY IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE
چکیده انگلیسی مقاله Background- In addition to traditional cardiovascular risk factors, high levels of plasma homocysteine has been documented recently as independent risk factors for atherosclerosis. The probable mechanism is through endothelial dysfunction. Roughly 10% of the population with coronary artery disease (CAD) may have hyper-homocysteinernia. Since folic acid is a potential factor in lowering plasma homocysteine and dietary intake of folic acid is not sufficient, it needs to be prescribed to CAD patients as a supplement. The purpose of this study is to assess the effect of folic acid on plasma homocysteine levels and on morbidity in stable CAD patients.Methods- In this prospective interventional study, we recruited 52 stable CAD patients; the plasma levels of homocysteine, folic acid and vitamin B12 were measured. The morbidity-related indices (the number of sublingual TNGs per week, typical anginal chest pain per week, the number of cardiovascular-related hospitalizations in the previous 3 months, functional class and ECG changes) were determined. All patients received 2 mg oral folic acid daily for 3 months. At the end of the study, the level of homocysteine and morbidity were determined.Results- Folic acid supplementation for 3 months was associated with a decrease in homocysteine level by 44% (P=0.000) We did not observe a significant change in levels of serum folic acid. There were significant declines in all morbidity indices including TNG consumption, frequency of chest pain, functional class and hospitalizations (P=0.001).Conclusion- The findings indicate that 2 mg folic acid orally daily for 3 months is associated with a decrease in homocysteine level and morbidity in CAD patients
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نویسندگان مقاله F. JALALI |


K.O. HAJIAN TILAKI |
DEPT. OF SOCIAL MEDICINE AND HEALTH, BABOL FACULTY OF MEDICINE, BABOL UNIVERSITY OF MEDICAL SCIENCES, BABOL, IRAN

نشانی اینترنتی http://journal.iha.org.ir/article_83980_87aa40b7b52d1749832d0397390300ac.pdf
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