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Iranian Heart Journal، جلد ۴، شماره ۴، صفحات ۶۸-۷۱
عنوان فارسی
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عنوان انگلیسی THE EFFECT OF GROWTH HORMONE ON IDIOPATHIC DILATED CARDIOMYOPATHY
چکیده انگلیسی مقاله Objective- Idiopathic dilated cardiomyopathy (IDCM) is currently an important cause ‎of mortality and morbidity due to chronic heart failure. The aim of our study was to ‎assess whether there could be any clinical and /or echocardiographic improvement in ‎patients with IDCM who had undergone treatment of recombinant human growth ‎hormone (GH).‎ ‎‎ ‎. Methods- Fourteen patients with IDCM and moderate heart failure (e.g. New York ‎Heart‏ ‏Association functional class II-III) were studied at base line, immediately and ‎‎3-months after treatment with GH. The study was a double-blind clinical trial. ‎Traditional treatment (e.g. digoxin, ACEI, B-blocker and diuretics) was continued ‎during the study. Cardiac performance was evaluated with clinical and ‎echocardiographic examinations.‎ ‎ Results- In spite of statistical improvements in the left ventricular ejection fraction ‎‎(LVEF)(mean ±SD from 35.6±5.9% at the base line of this study to 39.6%f6.7% ‎immediately and 39.3%f7.9% three months after treatment, p value < 0.05), other data ‎of the clinical and echocardiographic findings were not significantly different between ‎base line and post-treatment‏.‏‎‎ Conclusion- We conclude that 3-months of GH therapy in patients with idiop thic ‎dilated cardiomyopathy had little beneficial effects on cardiac mass and performance ‎‎(Iranian Heart Journal 2003; 4 (4):68-71‎‏(.‏
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نویسندگان مقاله K. A. Mohseni |
Imam Khomeini Hospital, Sari, Iran

V. Mokhberi |


S. Abdi |


نشانی اینترنتی http://journal.iha.org.ir/article_83653_b2cc4313b87754d9d9cf10a1c24c6157.pdf
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