این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Veterinary Research Forum، جلد ۱، شماره ۳، صفحات ۱۵۰-۱۵۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Disposition Kinetics of Amoxicillin in Healthy, Hepatopathic and Nephropathic Conditions in Chicken after Single Oral Administration
چکیده انگلیسی مقاله Fifteen broiler chickens (COBB 400) of 42 days of age weighing 1.8 to 2.0 kg were equally divided into 3 groups, each consisting of 5 birds. Hepatopathy was induced by oral administration of paracetamol while nephropathy was induced by intravenous administration of uranyl nitrate. Kinetic study was investigated in healthy, hepatopathic and nephropathic birds following single oral administration of amoxicillin at 40 mg kg-1. Blood samples were collected at different time schedule. Plasma concentrations of amoxicillin in healthy, hepatopathic and nephropathic birds were 41.90 ± 5.59, 9.93 ± 0.76 and 38.75 ± 6.08 μg ml-1, respectively at 1 hr; 15.34 ± 1.99, 18.57 ± 1.66 and 67.40 ± 2.62 μg ml-1, respectively at 4 hr and 2.03 ± 0.28, 15.54 ± 0.82 and 30.63 ± 1.58 μg ml-1, respectively at 24 hr. Maximum plasma concentration was detected at 1 hr in healthy birds (41.90 ± 5.59 μg ml-1 ), at 8 hr in hepatopathic birds (23.51 ± 1.64 μg ml-1) and at 4 hr in nephropathic birds (67.40 ± 2.62 μg ml-1). The drug could not be detected in plasma beyond 24 hr in healthy, 72 hr in both hepatopathic and nephropathic birds. The concentration of amoxicillin was significantly (P < 0.01) higher in most of the samples of hepatopathic and nephropathic birds compared to healthy birds. Significant higher values (P < 0.01) of t1/2 K, AUC, and MRT and lower values of K and ClB in the hepatopathic and nephropathic birds in comparison to healthy birds were observed.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله moloy کومار bhar | moloy kumar
department of pharmacology and toxicology, west bengal university of animal and fishery sciences, mohanpur campus, nadia, west bengal, india, pin 741252

bakul کومار datta | bakul kumar
department of pharmacology and toxicology, west bengal university of animal and fishery sciences, mohanpur campus, nadia, west bengal, india, pin 741252

pabitra hridoy patra | pabitra hridoy
department of pharmacology and toxicology, west bengal university of animal and fishery sciences, mohanpur campus, nadia, west bengal, india, pin 741252

jeevan ranjan داش | jeevan ranjan
department of pharmacology and toxicology, west bengal university of animal and fishery sciences, mohanpur campus, nadia, west bengal, india, pin 741252

tapas کومار سید علیرضا | tapas kumar
department of pharmacology and toxicology, west bengal university of animal and fishery sciences, mohanpur campus, nadia, west bengal, india, pin 741252

animesh کومار chakraborty | animesh kumar
department of pharmacology and toxicology, west bengal university of animal and fishery sciences, mohanpur campus, nadia, west bengal, india, pin 741252

tapan کومار mandal | tapan kumar
department of pharmacology and toxicology, west bengal university of animal and fishery sciences, mohanpur campus, nadia, west bengal, india, pin 741252

نشانی اینترنتی http://vrf.iranjournals.ir/article_1514_666498c76e78480626e0d8ab20d1f85d.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات