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International Journal of Fertility and Sterility، جلد ۱۳، شماره ۲، صفحات ۱۴۸-۱۵۳
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عنوان انگلیسی Impact of Metformin and Pioglitazone on Serum Level of Tumor Necrosis Factor-Alpha and Lipid Profiles during Implantation Window in Diabetic Rats
چکیده انگلیسی مقاله Objective: Objectives: The present study was designed to evaluate the serum lipid profile and Tumor Necrosis Factor alpha (TNF-ɑ) level in diabetic rats at the time of implantation. Type 2 diabetes mellitus (T2DM) could affect various systems, including innate immune system and causes chronic low-grade inflammation which increases the level of TNF-ɑ. Furthermore, T2DM is often accompanied by impaired lipid profile. Metformin and pioglitazone are used as the first and second line of treatment for T2DM. Materials and methods: Thirty-five adult virgin female wistar rats weighting 175-225 g were randomly categorized into five groups: (1) control (2) sham (3) Nicotinamide (NA)+Streptozotocin (STZ) induced T2DM, (4) Diabetic + pioglitazone (20 mg/kg/day for 28 days per oral) and (5) Diabetic + metformin (100 mg/kg/day for 28 days per oral). At the time of implantation, TNF-ɑ level in serum of rats was measured by ELISA kit. Glucose was measured using photometric method and lipid profiles were calculated by enzymatically methods. Results: The level of TNF-ɑ in the diabetic group was significantly higher than other groups (P< 0.001). Also, in metformin treated group, TNF-ɑ serum level was significantly higher than pioglitazone treated group (P< 0.001). FBS and lipid profiles was significantly higher in diabetic group. Conclusion: : Metformin and pioglitazone have obvious similar effects on glucose, lipid profiles and TNF-ɑ serum levels. Through these drugs, pioglitazone has more efficient influence on TNF-α serum level in comparison with metformin.
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نویسندگان مقاله | Abbas Bakhteyari


| Parvaneh Nikpour


| Fatemah sadat Mostafavi


| Nahid Eskandari


| Mohammad Matinfar


| Sara Soleimani Asl


| Roshanak Aboutorabi


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5636
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-1451201.pdf
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