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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۶، صفحات ۶۳۷-۶۴۲
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عنوان انگلیسی Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats
چکیده انگلیسی مقاله Objective(s): Maternal high-fat diet (HFD) consumption has been linked to metabolic disorders and reproductive dysfunctions in offspring. Troxerutin (TRO) has anti-hyperlipidemic, anti-oxidant, and anti-inflammatory effects. This study examined the effects of TRO on apelin-13, its receptors mRNA and ovarian histological changes in the offspring of HFD fed rats. Materials and Methods: Female Wistar rats were randomly divided into control diet (CD) or HFD groups and received these diets for eight weeks. After mating, dams were assigned into four subgroups: CD, CD + TRO, HFD, and HFD + TRO, and received their respective diets until the end of lactation. Troxerutin (150 mg/kg/day) was gavaged in the CD + TRO and HFD + TRO groups during pregnancy. On the postnatal day (PND) 21 all female offspring were separated and fed CD until PND 90. On PND 90 animals were sacrificed and ovarian tissue samples were collected for further evaluation. Results: Results showed that HFD significantly decreased serum apelin-13 in the female offspring of the HFD dams, which was significantly reversed by TRO. Moreover, real-time polymerase chain reaction (PCR) analysis revealed that TRO treatment significantly decreased the ovarian mRNA expression of the apelin-13 receptor in the troxerutin-received offspring. Furthermore, histological examination revealed that TRO increased the number of atretic follicles in the ovaries of HFD+TRO offspring.Conclusion: Maternal high fat feeding compromises ovarian health including follicular growth and development in the adult offspring and troxerutin treatment improved negative effects of maternal HFD on the apelin-13 level and ovarian development of offspring.
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نویسندگان مقاله | Keivan Mehri
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Seyed Mehdi Banan Khojasteh
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Iran


| Fereshteh Farajdokht
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran


| Zohreh Zavvari Oskuye
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Hadi Ebrahimi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Rogaye Diba
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Parvin Bayandor
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Maryam Hosseindoost
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Shirin Babri
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12762.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1454251.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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