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Basic and Clinical Cancer Research، جلد ۱۱، شماره ۲، صفحات ۳۱۲-۳۱۲
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عنوان انگلیسی Estrogen receptor alpha gene single nucleotide polymorphisms and breast cancer risk, a hospital based case-control study
چکیده انگلیسی مقاله Background: Estrogen is a risk factor for development of breast cancer. The effect of estrogen is primarily mediated by estrogen receptor alpha 1 (ESR1). In this study, we investigated the association of breast cancer risk with the frequency of alleles and genotypes for two ESR1 single nucleotide polymorphisms (SNPs) in breast cancer patients and healthy control group.   Methods: A total of 98 female patients with pathologically confirmed breast cancer and 93 female age-matched healthy controls from the visitors of general hospital were recruited. Two ESR1 candidate polymorphisms +2464 C/T (rs3020314) and -4576A/C (rs1514348) were selected. Frequency of alleles and genotypes was determined by Quantitative Real-Time PCR assay. Linkage disequilibrium (LD) was assessed for each pair of markers. Using logistic regression, genotype frequencies were estimated as odds ratios with 95 % confidence intervals. Results: There was not a significant difference in genotype and allele distributions of the ESR1 for SNPs +2464 C/T and SNP -4576A/C between patients and controls. The frequency of ESR1 +2464 T/T genotype in case and control groups was 31.6% vs 29.0%, (OR TT/TC: 1.13, 95%CI: 0.58, 2.20; P = 0.69). The frequency of +2464C allele was 33.9% vs 35.2%, (OR C/T: 0.94, 95%CI: 0.60, 1.47; P =0.79). The frequency of ESR1 -4576C/C genotype in case and control groups was 37.75% vs 33.36 %, OR CC/AC: 1.02, 95%CI: 0.51, 1.97; P =0.98). The frequency of -4576A allele was 36.2% vs 43.6 %, (OR C/A: 0.73, 95%CI: 0.47, 1.13; P =0.14). Conclusion: The results indicated that ESR1 polymorphism does not show any significant association with breast cancer risk among female Iranian adults. Further studies with large sample size are needed.
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نویسندگان مقاله | Ali Akbar Amirzargar
Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Maryam Sadr
Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Majid Mahmoodi
Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Samira Esmaeili Reykande
Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Elham Mohebbi
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences. Tehran, Iran.


| Mohammad Shirkhoda
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences. Tehran, Iran
نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/312
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