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Middle East Journal of Cancer، جلد ۱۰، شماره ۲، صفحات ۱۰۳-۱۱۰
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عنوان انگلیسی Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study
چکیده انگلیسی مقاله Background: In this study, we sought to understand the usefulness of salivary lactatedehydrogenase as a predictive marker for the development of radiation-inducedmucositis.Methods: This was a prospective study with head and neck cancer patients whorequired curative radiotherapy (>60Gy). We collected patients' saliva before the onsetof radiation and after 2 Gy of radiation to assess lactate dehydrogenase levels. The patientsreceived the stipulated oral and dental care. Data on incidence and severity of mucositiswas collected using a preform sheet and oral mucositis assessment scale published bythe Radiation Therapy Oncology Group throughout the 7-week treatment period.Results: Salivary lactate dehydrogenase increased with exposure to radiation(P< 0.0001) and there was an observed association with mucositis severity (P< 0.0001;r = 0.515).Conclusion: The present results have established, for the first time, that salivarylactate dehydrogenase could be a useful predictive marker to understand the developmentof radiation-induced mucositis in patients with head and neck cancer. The proximityof the oral cavity for regular observation and saliva collection is an added advantage.
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نویسندگان مقاله Arnadi R Shivashankara |
Departments of Biochemistry Father Muller Medical College, Mangalore, Karnataka, India

Raees Tonse |
Radiation Oncology Father Muller Medical College, Mangalore, Karnataka, India

Sucharitha Suresh |
Community Medicine, MBBS student, Father Muller Medical College, Mangalore, Karnataka, India

Thomas George |
Community Medicine, MBBS student, Father Muller Medical College, Mangalore, Karnataka, India

Mamidipudi Srinivasa Vidyasagar |
Radiation Oncology Father Muller Medical College, Mangalore, Karnataka, India

Suresh Rao |
Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India

Manjeshwar Shrinath Baliga, |
Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India

نشانی اینترنتی http://mejc.sums.ac.ir/article_44859_25a77eb0a3a8664311a93c181a8dcf2d.pdf
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