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Iranian Biomedical Journal، جلد ۲۳، شماره ۴، صفحات ۲۸۷-۲۹۶
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عنوان انگلیسی Pharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice after Intravenous and Oral Administration
چکیده انگلیسی مقاله Introduction: Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice. Methods: 131I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12.5 mg/kg. Mice were sacrificed and blood samples, major organs, and tumor were taken at 10, 20, 40, 90, 180, 300, 480, and 1440 min. Results: For IV route, maximum peak concentration (Cmax), elimination half-lives, total body clearance (CL), distribution volume (Vd), mean residence time (MRT), and area under curve (AUC) were 21.77 ± 2.45 %Dosis·h/mL, 12.65 ± 2.1 h, 4.59 ± 0.23 mL/h, 83.80 ± 12 mL, 12.49 ± 2.71 h, and 21.77 ± 2.45 %Dosis·h/mL, respectively. For  PO route, they were 0.60 ± 0.07 %Dosis·h/mL, 9.33 ± 1.35 h, 36.94 ± 4.01 mL/h, 497.33 ± 30 mL, 12.40 ± 1.87 h, and 6.89 ± 1.18 %Dosis·h/mL, respectively. PK parameters (Cmax, CL, Vd, and AUC) showed significant differences between IV and PO routes. Bioavailability was 31.6 ± 4% for PO dose. Kidney, stomach, liver, and lung for IV and stomach, kidney, spleen, and lung for PO routes showed the major uptakes for 131I-labeled venom. In tumor tissue, after the maximum uptake for both routes, there was a consistent behavior of radioactivity respect to the major organs during the first 480 min. Conclusion: The PK and BD of R. junceus venom in mice depend on the administration route. These data represent a starting point for future experiments with this scorpion venom in experimental models of cancer.
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نویسندگان مقاله | Alexis Díaz-García
Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana, Cuba


| Gilmara Pimentel González
Radiopharmacy Laboratory, Oncology and Radiobiology National Institute, Havana, Cuba


| Tais Basaco Bernabeu
Radiopharmacy Laboratory, Oncology and Radiobiology National Institute, Havana, Cuba


| Juan C. Rodríguez Aurrecochea
Research Department, Laboratory of Experimental pathology, Oncology and Radiobiology National Institute, Havana, Cuba


| Hermis Rodríguez Sánchez
Microbiology Department, Cell culture Laboratory, Tropical Medicine Institute “Pedro Kourí”, Havana, Cuba


| Iraida Sánchez Monzón
Radiopharmacy Laboratory, Oncology and Radiobiology National Institute, Havana, Cuba


| Maikel Hernández Gómez
Radiopharmacy Laboratory, Oncology and Radiobiology National Institute, Havana, Cuba


| Caridad Rodríguez Torres
Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana, Cuba


| Maria Regla Rodríguez Capote
Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana, Cuba


| Irania Guevara Orellanes
Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana, Cuba
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-768&slc_lang=en&sid=1
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