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Acta Medica Iranica، جلد ۵۷، شماره ۳، صفحات ۱۵۲-۱۵۵
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عنوان انگلیسی Evaluation of serum protein carbonyl level and total antioxidant capacity in patients with basal cell carcinoma
چکیده انگلیسی مقاله Background: Basal cell carcinoma (BCC) is one of the most common types of human cancer. Since oxidative stress is believed to be one of the pathogenic mechanisms involved in BCCformation, understanding the probable relation of inflammatory oxidative factors, such as serum protein carbonyl and total antioxidant capacity, to BCCcan help identify other pathogenic aspects of this tumor. Methods: Forty cases of BCC and forty cases of healthy controls without BCCor any other systemic disease were included in this study. After 5-ml venous blood samples were obtained from each patient, the separated serum fractions were stored at -70°C until analysis. Results: Serum protein carbonyl level in the BCC group was significantly higher than that in the healthy controls((5.86 ± 3.25 µM vs. 0.86 ± 0.20 µM, p < 0.001). The average serum total antioxidant capacitywas 3.41±0.05 mM in the BCC group and 1.15 ± 0.03mM in the control group (statistically significant at p < 001). Conclusion: Oxidative stress might play a role in the pathogenesis of BCC.
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نویسندگان مقاله | Seyed Isaac Hashemy
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Ahmad Reza Taheri
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Morteza Behnamfard
Mashhad University of Medical Sciences, Mashhad, Iran


| Mehrdad Teimourian


| Sara Sabouri Rad
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7341
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