این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Addiction and Health، جلد ۱۰، شماره ۳، صفحات ۱۸۰-۱۸۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Heart Reaction to Nandrolone Decanoate plus Two Different Intensities of Endurance Exercise: Electrocardiography and Stereological Approach
چکیده انگلیسی مقاله Background: Regarding the negative effects of androgenic anabolic steroids (AASs) abuse, the long-term effect of nandrolone decanoate with/without two intensities of endurance exercise training was investigated on heart tissue and electrocardiogram (ECG) in rats. Methods: The experiment was conducted on 63 male Wistar rats, which were 4 months old. The rats were divide into groups of control (CTL), arachis oilasnandrolone solvent (Ar), nandrolone (Nan) (received a dose of 5 mg/kg twice/week for 8 weeks), mild swimming exercise training (mEx), severe exercise (sEx), sEx + Nan, mEx + Nan, mEx + Ar, and sEx + Ar. During the 8 weeks of swimming exercise, the animals carried dumbbells equivalent to 2% of their body weight, which was gradually increased and reached 5% and 8% in the 6th week for mild and severe exercises, respectively. Finally, ECGs recording and samplings were done. Findings: Both types of exercise, without nandrolone, significantly reduced the heart rate and increased the RR interval of ECG. Nandrolone alone and with mild (P < 0.050) and intense exercise (P < 0.010 vs. CTL) increased the left ventricular hypertrophy (LVH) index. Left ventricular volume was significantly higher in the Nan group (P < 0.050) compared to the CTL group and all exercise groups (P < 0.010) compared to the Nan, CTL, and Ar groups. Myocytes volume increased in the presence of both of mild and high-intensity exercise plus nandrolone (P < 0.050 vs. CTL and Ar groups). Hydroxyproline value of the heart was significantly higher in the nandrolone group compared to all other groups (P < 0.001). Exercise prevented the effect of nandrolone on hydroxyproline. Conclusion: Both levels of swimming exercise prevent the effect of nandrolone on the production of hydroxyproline and fibrotic cardiac remodeling.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله Siyavash Joukar |
Associate Professor, Neuroscience Research Center, Institute of Neuropharmacology AND Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences AND Physiology Research Center AND Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Vida Naderi-Boldaji |
Physiology Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Ir

Mahdieh Yoosefnia |
General Practitioner, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Ira

Hamidreza Nasri |
Associate Professor, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Cardiology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Forouzan Rafie |
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

نشانی اینترنتی http://ahj.kmu.ac.ir/article_85177_de8c12113113ed08877db66f7dc69a4b.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/166/article-166-1502230.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات