| چکیده انگلیسی مقاله |
Background: Monitoring of chemokines, CXCL9 and CXCL10, in serum may present a non-invasive detection method for rejection. Objective: To investigate the relationship between urinary levels of CXCL9 and CXCL10 and graft function following renal transplantation. Methods: 75 living-related donor renal transplant recipients were studied. Urinary levels of chemokines were collected pre-operatively, on post-operative 1 st day, 7 th day, 1 st month, 3 rd month, and at the time of rejection. Chemokines levels were assayed using and enzyme-linked immunosorbent assay. Results: Clinical variables were monitored. 10 (15%) patients had biopsy-proven rejection during the follow-up period. The urinary CXCL9 level in those with rejection was significantly higher than that in those with non-rejection group at the 1 st day (p< 0.001), 7 th day (p< 0.001), and at the time of rejection (p=0.002). The urinary CXCL10 level was also significantly higher in those with rejection compared with non-rejection group at 1 st day (p< 0.001), 7 th day (p< 0.001), and at the time of rejection (p=0.001). Serum creatinine level was strongly correlated with the urinary CXCL9 and CXCL10 levels at the time of rejection (r=0.615, p=0.002; and r=0.519, p=0.022, respectively). Among those with T cell-mediated rejections the mean urinary CXCL10 level increased to as high as 258.12 ng/mL. Conclusion: Urinary CXCL9 and CXCL10 levels might have a predictive value for T cell-mediated rejection in early post-transplantation period. Measurement of urinary CXCL9 and CXCL10 levels could provide an additional tool for the diagnosis of rejection. |
| نویسندگان مقاله |
| H Senturk Ciftci
Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| T Tefik
Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| M K Savran
Department of Anesthesia, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| E Demir
Department of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| Y Caliskan
Department of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| Y D Ogret
Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| T Oktar
Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| O Sanlı
Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| T Kocak
Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| Y Ozluk
Department of Pathology, Istanbul Faculty of
Medicine, Istanbul University, Istanbul, Turkey
| F S Oguz
Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| I Kilicaslan
Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
| F Aydın
Department of Medical Biology and Genetics, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey
| A Turkmen
Department of Nephrology, Istanbul Faculty of
Medicine, Istanbul University, Istanbul, Turkey
| I Nane
Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
|