این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۱۵، شماره Special Issue-۱۲th. Iranian Congress of Medical Physics، صفحات ۹۲-۹۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hypopituitarism in adult patients with non-pituitary brain cancer following radiation therapy
چکیده انگلیسی مقاله Introduction:  The purpose and our novelty of the current study were to evaluate the HPA function in adult survivors of primary non-pituitary brain tumors and its association with treatment-related factors such as received dose to the organs at risk, age at irradiation, surgery, and adjuvant chemotherapy in patients treated with RT for brain tumors. Moreover, it aimed to achieve the threshold incidence of late effects because of irradiation to HPA, improve the management of these patients, and improve their quality of life after treatment. Methods and Materials: Thirty-one (31) patients treated with primary or postoperative radiotherapy (RT) for various cancers in the brain region without pre-existing hypothalamic pituitary (HP) disorder from other causes were prospectively evaluated. Serum samples were obtained from the patients to determine levels of growth hormone (GH), thyroid- stimulating hormone (TSH), and free thyroxine (FT4). Serum samples were measured before treatment, 3 and 6 months after completion of radiation therapy (RT). The hypothalamus- pituitary axis (HPA) and dose volume histograms (DVH) of the patients were derived from their computed tomography-based treatment plans. Results: Clinical hypopituitarism was not observed, but 83% of patients who tested for hypopituitarism demonstrated subclinical hypopituitarism after a median interval of 6 months. Subclinical GH and TSH deficiency were observed in 17 (54%) and 9 (29%) participants, respectively. Significant declines in TSH (p < 0.021), FT4 (p < 0.009), and T4 (p < 0.036) levels after the RT course that can be interpreted as subclinical central hypothyroidism were observed. Adjuvant chemotherapy and surgery did not significantly influence the hypopituitarism (p = 0.698, p = 0.287, respectively). The doses of radiation to the HPA region ranged from 241 to 5941 cGy (2.4-59.4 Gy). The mean received dose (Dmean) and biological effective dose (BED) to the pituitary were 36 and 59.6 Gy, respectively. Conclusions: Subclinical findings of late radiation effects were observed in the HPA. Radiation-induced hypopituitarism and central hypothyroidism are regarded as primary damage to the pituitary gland. The damage is dependent on follow-up. Neuronal cell death and degeneration because of the direct effects of radiation seem to play basic roles
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Jalal Ordoni
MSC of Radiobiology, Department of Radiology, Faculty Member of Paramedicine, Zahedan University of Medical Sciences, Zahedan, Iran


| Dariush Askari
MSC of Radiobiology, Department of Radiology, Faculty of Paramedicine, Shahid Beheshti University of Medical Science, Tehran, Iran


| Yazdan Salimi
MSC of Medical Physic, Department of Biomedical Engineering and Medical Physics, Faculty of medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
نشانی اینترنتی http://ijmp.mums.ac.ir/article_12420.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Conference Proceedings
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات