این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۱۵، شماره Special Issue-۱۲th. Iranian Congress of Medical Physics، صفحات ۲۷۳-۲۷۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Sensory Pathways in Spinal Cord by Comparison of fMRI Methodologies
چکیده انگلیسی مقاله Introduction: Today, clinicians and neuroscientists need to have a comprehensive survey of neurological pathologies and injuries. For the First-time, SEEP contrast and Spin-Echo pulse sequences was used for functional imaging of the Lumbar spinal cord. This method used by several research groups for Spinal cord mapping, but other researchers tried to improve BOLD fMRI to Spinal cord imaging simultaneously. Here, we present a comparison between useful imaging methods and finally use of certain procedure for Spinal cord mapping with sensory stimulation. Materials and Methods: We planned two imaging protocols on Siemens 3T magnetom trio scanner: HASTE/SSFP, TE/TR: 76mS/6750mS for 9 sagittal slices with 2 mm thickness, FOV= 280×210mm, and Gradient Echo EPI, TE/TR: 30S/3000mS for 21 axial slices with 5mm thickness, FOV= 64×64mm. These image acquisition procedures performed on All 5 subjects (male, Age: 24.6±2.05), stimulated by 60g von Frey filament. Stimulations were used in the block design, 8 blocks with time 40.5 S for SE protocol and 42 S for GRE protocol and performed on right foot L4 dermatome. We entered each subject's data sets into an individual first-level statistical analysis. Then we calculated signal changes in the mask that generated in the statistical analysis and amount of temporal Signal to Noise Ratio (tSNR). Other subjects group (5 males, Age 25.3±1.5) was imaged with same protocol as GE-EPI and T2W anatomic images (3D-FSE Isotropic, TR/TE:1500/430 ms, FOV= 256×60 mm, slice-thickness: 1mm). Data sets were processed with GLM and Finally, all first-level analysis results are entered in Higher-level analysis as group analysis and obtained statistical maps for spinal cord functions. Results: We observed different tSNR in two separated datasets, 2.619 ± 0.440 for SE-HASTE images and 4.901 ± 0.762 for GRE-EPI. After statistical analysis of images and obtaining signal change in the spinal cord. We comprised them and measured signal change was 1.737 ± 1.252 for SE-EPI and 2.554 ± 1.327 for GE-EPI. Based on these results we decided to use GE- EPI for spinal cord functional imaging. We stimulated L4 dermatome and this localized activation was observed in the T9-T1. The activation maps show ipsilateral synapse and tracks in the dorsal higher than ventral horn. Conclusion: At the first step evaluation of imaging methods show GRE-EPI can more efficient for Lumbar functional MRI and detection of BOLD signal change in the spinal cord. This research demonstrates the benefits of spinal cord fMRI for mapping of sensory stimulation. The resulting activity maps show primarily in ipsilateral dorsal regions and in some ventral regions, consistent with the spinal cord anatomy. These data also illustrate details of the sensory organization of the spinal cord, as well as anatomical detail of the spinous processes and positions of nerve roots.
کلیدواژه‌های انگلیسی مقاله Spinal Cord, fMRI, BOLD, SEEP, Sensory Pathway
نویسندگان مقاله | Hamed Dehghani
Department of Medical Physics and Biomedical engineering, Tehran University of Medical Sciences, Tehran, Iran Neuro-Imaging and Analysis Group (NIAG), Tehran University of Medical Sciences, Tehran, Iran.


| Mohammad Ali Oghabian
Department of Medical Physics and Biomedical engineering, Tehran University of Medical Sciences, Tehran, Iran Neuro-Imaging and Analysis Group (NIAG), Tehran University of Medical Sciences, Tehran, Iran.


| Amir Hossein Batouli
Neuro-Imaging and Analysis Group (NIAG), Tehran University of Medical Sciences, Tehran, Iran.


| Ali Khatibi
McConnel Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada
نشانی اینترنتی http://ijmp.mums.ac.ir/article_12921.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Conference Proceedings
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات