| چکیده انگلیسی مقاله |
Background and Objectives: HIV enteropathy may cause disruption of the intestinal barrier, leading to a loss of CD4+ T cells, increased intestinal permeability, and microbial translocation. Lactobacillus plantarum IS-10506 has the ability to improve gut barrier function. This study investigated the effect of L. plantarum IS-10506 on a number of biomarkers of enteropathy-related damage in HIV-infected paediatric patients undergoing antiretroviral therapy (ARV).
Materials and Methods: A randomized, double-blind, placebo-controlled study was conducted on 2-18 year-old children, diagnosed as HIV infected according to the WHO 2007 criteria who had received ARV for ≥ 6 months. Subjects were excluded if ARV therapy was discontinued or the patients took probiotics ≥ 2 weeks prior to the study or during the study period. Subjects were randomized into a probiotic group and placebo group. The probiotic group received L. plantarum IS-10506 2.86 × 1010 cfu/day for 6 days. Blood lipopolysaccharide (LPS) level, serum CD4+ T cell count, serum CD8+ T cell count, CD4+/CD8+ T cell ratio, and faecal sIgA level were assessed as biomarkers.
Results: Twenty-one subjects completed this study. The blood LPS level decreased significantly in the probiotic group (p = 0.001). There was no significant difference in absolute CD4+ T cell count, percent CD4+ cells, absolute CD8+ T cell count, CD4+/CD8+ T cell ratio, or faecal sIgA. No serious adverse events were reported.
Conclusion: The probiotic L. plantarum IS-10506 reduced the blood LPS level but showed no effect on the humoral mucosa and systemic immune response in HIV-infected children undergoing ARV therapy. |
| نویسندگان مقاله |
| Alpha Athiyyah
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Herwina Brahmantya
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Stephani Dwiastuti
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Andy Darma
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Dwiyanti Puspitasari
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Dominicus Husada
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Reza Ranuh
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Anang Endaryanto
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
| Ingrid Surono
Food Technology Department, Faculty of Engineering, Bina Nusantara University, Jakarta, Indonesia
| Subijanto Sudarmo
Department of Child Health, Faculty of Medicine, Dr. Soetomo Hospital, Airlangga University, Surabaya, Indonesia
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