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Iranian Journal of Microbiology، جلد ۱۱، شماره ۲، صفحات ۱۶۰-۱۶۵
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عنوان انگلیسی Effect of microencapsulation on Saccharomyces cerevisiae var. boulardii viability in the gastrointestinal tract and level of some blood biochemical factors in wistar rats
چکیده انگلیسی مقاله Background and Objectives: Probiotics are live microorganisms that, when administered in an adequate amount, confer a health benefit on the host through the gut. Saccharomyces cerevisiae is a widespread yeast found in nature. This microorganism has been used as a probiotic agent in recent years. In this study, the effect of microencapsulation on survival rate of S. cerevisiae var. boulardii in the simulated gastrointestinal tract medium and the impact of microencapsulated S. cerevisiae var. boulardii on some serum biochemical factors in a rat model was evaluated. Materials and Methods: 30 male wistar rats were divided into three groups (control, rats receiving microencapsulated S. cerevisiae var. boulardii, and rats receiving S. cerevisiae var. boulardii alone). The probiotic was gavaged at a dosage of 2 gr/kg BW for 8 weeks. Blood was collected from rats at the end of the treatment period and biochemical factors were measured using Mancompany kits. Results: The results showed a significant increase in viability of microencapsulated S. cerevisiae var. boulardii in comparison with free S. cerevisiae var. boulardii (p< 0.05). Weight of rats in probiotic treated groups was significantly higher in comparison with the control group (p< 0.05). Moreover, probiotic treatment reduced mean levels of triglycerides, cholesterol, free blood sugar and liver enzymes in rats. Conclusion: Microencapsulation could increase the survival rate of yeast probiotics in the gastrointestinal tract; however, more studies are needed for better understanding of the exact effect of microencapsulation on probiotics’ function.
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نویسندگان مقاله | Hassan Ghorbani-Choboghlo
Department of Medical Mycology, AJA University of Medical Sciences, Tehran, Iran


| Donya Nikaein
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran


| Ali-Reza Khosravi
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran


| Reza Rahmani
Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Zohreh Farahnejad
Department of Medical Mycology, AJA University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/1878
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