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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۳، صفحات ۲۰۱-۲۰۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective effects of melatonin solid lipid nanoparticles on testis histology after testicular trauma in rats
چکیده انگلیسی مقاله Testicular traumatic injuries occur frequently, which can result in an alteration in spermatogenesis.These injuries can also cause oxidative stress and male infertility. Antioxidant efficiency of melatonin (MLT), known as a potent antioxidant, will be improved if used in a form of solid lipid nanoparticles (MLT-SLN). The aim of the current study is to evaluate the effect of MLT-loaded SLN on traumatic testis in rats. In this study 32 adult male Wistar rats were divided into 4 groups. Group 1 (sham group), right testicle was drawn out from the scrotum and returned without manipulation. Group 2, right testicle was dropped by 25 g sinker for 4 times. Group 3, animals were received a single dose (25 mg/kg) of MLT intraperitoneally after trauma. Group 4, animals were received a single dose of MLT-SLN intraperitoneally after trauma. Under anaesthesia, rats were sacrificed, and their testicles were removed three days after the surgery. After tissue processing, the sample sections were H&E stained. MLT and MLT-SLN could partially repair spermatogenesis by Johnson's criteria but the repairs were significant only in MLT-SLN group ( P = 0.02). Trauma decreased seminiferous tubule diameter and its epithelium height. MLT could restore epithelium height ( P ≤ 0.05) but its NPs improved both epithelium diameter ( P ≤ 0.05) and thickness ( P ≤ 0.001). The Malondialdehyde increased significantly in trauma group ( P = 0.002), but decreased in MLT and NPs groups compared to trauma group ( P = 0.098 and P = 0.002 respectively). This decrease was significant only in NPs group. Testicular trauma disturbed spermatogenesis, morphometric, and oxidative parameters. MLT and specially MLT-SLN improved traumatic damages. 
کلیدواژه‌های انگلیسی مقاله Melatonin,Nanoparticles,Rats,Testis.
نویسندگان مقاله | Mehri Mirhoseini
3Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Zahra Rezanejad Gatabi
3Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, I.R. Iran. 4Pharmaceutical Sciences Research Center, Haemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Majid Saeedi
5Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Katayoun Morteza-Semnani
2Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran. 6Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran


| Fereshteh Talebpour Amiri
4Pharmaceutical Sciences Research Center, Haemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Hamid Reza Kelidari
2Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran. I.R. Iran. 6Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, I.R. Iran.


| Abbas Ali Karimpour Malekshah


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1895
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1566608.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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