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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۳، صفحات ۲۴۷-۲۵۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synthesis and cytotoxic evaluation of novel quinozalinone derivatives with substituted benzimidazole in position 3
چکیده انگلیسی مقاله Quinazolinone and benzimidazole are both fused heterocyclic compounds which have shown valuable biological properties including cytotoxic, antibacterial, and antifungal activities. In this study, a series of novel quinazolinone derivatives substituted with benzimidazole were synthesized in two parts. In the first part 2 - phenyl - 1 H - benzimidazol - 6 - amine ( 4 ) was synthesized from the reaction of 4-nitro-o-phenylenediamine and benzoic acid. In the second part, new 3-(2-phenyl-1 H benzoimidazol-5-yl)-3H-quinazolin-4-one derivatives ( 8a-8f ) were also prepared. Finally compound 4 was reacted with the different benzoxazinone derivatives ( 8a-8f ) to give the target compounds. The structures of the synthesized compounds were confirmed by IR and 1 HNMR. Cytotoxic activities of the final compounds were assessed at 100, 200, 300, 400, and 500 μM against MCF-7 and HeLa cell lines using the MTT colorimetric assay. Almost all compounds exhibited good cytotoxic activity against both cell lines. Compound 9d demonstrated the highest cytotoxic activity against MCF7 and Hela cell lines with IC 50 70 μM and 50 μM, respectively.
کلیدواژه‌های انگلیسی مقاله Cytotoxicity,Benzimidazole,MTT assay,Quinazolinone.
نویسندگان مقاله | Elham Taherian
1Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. 2Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Ghadamali Khodarahmi
2Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Marzieh Rahmani Khajouei
1Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Farshid Hassanzadeh
3Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Nasim Dana


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1900
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1566613.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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