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Iranian Journal of Medical Sciences، جلد ۴۱، شماره ۳، صفحات ۱۸۰-۱۸۵
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عنوان انگلیسی Effects of Arbutin on Radiation-Induced Micronuclei in Mice Bone Marrow Cells and It's Definite Dose Reduction Factor
چکیده انگلیسی مقاله Background: Interactions of free radicals from ionizing radiation with DNA can induce DNA damage and lead to mutagenesis and carsinogenesis. With respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation.In the present study, the effects of arbutin were investigated by using the micronucleus test for anti-clastogenic activity, to calculate the ratio of polychromatic erythrocyte to polychromatic erythrocyte plus normochromatic erythrocyte (PCE/PCE+NCE) in order to show cell proliferation activity.Methods: Arbutin (50, 100, and 200 mg/kg) was intraperitoneally (ip) administered to NMRI mice two hours before gamma radiation at 2 and 4 gray (Gy). The frequency of micronuclei in 1000 PCEs (MnPCEs) and the ratio of PCE/PCE+NCE were calculated for each sample. Data were statistically evaluated using one-way ANOVA, Tukey HSD test, and t-test.Results: The findings indicated that gamma radiation at 2 and 4 Gy extremely increased the frequencies of MnPCE (P< 0.001) while reducing PCE/PCE+NCE (P< 0.001) compared to the control group. All three doses of arbutin before irradiation significantly reduced the frequencies of MnPCEs and increased the ratio of PCE/PCE+NCE in mice bone marrow compared to the non-drug-treated irradiated control (P< 0.001). All three doses of arbutin had no toxicity effect on bone marrow cells. The calculated dose reduction factor (DRF) showed DRF=1.93 for 2Gy and DRF=2.22 for 4 Gy.Conclusion: Our results demonstrated that arbutin gives significant protection to rat bone against the clastogenic and cytotoxic effects of gamma irradiation.
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نویسندگان مقاله Saba Nadi |
Department of Radiobiology and Radiation Protection, Babol University of Medical Sciences, Babol, Iran

Ali Shabestani Monfared |
Cellular & Molecular Biology Research Center, Department of Medical physics, Babol University of Medical Sciences, Babol, Iran

Hossein Mozdarani |
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Aziz Mahmodzade |
Laboratory of Cytogenetic, Novin Medical Radiation Institute, Tehran, Iran

Mahdi Pouramir |
Department of Biochemistry, Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran

نشانی اینترنتی http://ijms.sums.ac.ir/article_40353_39056d98c28390d06d1433068bb01f56.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-1611497.pdf
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