این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Sciences، جلد ۳۲، شماره ۱، صفحات ۲۲-۲۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effects of Human New Pressor Protein and Coagulation Factor XIIa on Blood Pressure and Heart Rate in Bilaterally Nephrectomized Rats
چکیده انگلیسی مقاله Background: New Pressor Protein (NPP) is a human plasma enzyme structurally related to b–fragment of activated factor XІІ (β-FXIIa). The objective of the present study was to investigate the effects of NPP and β-FXIIa on systolic blood pressure and heart rate in bilateral nephrectomized rats. Methods: Forty male Wistar rats (250-300 g) were sham-operated or bilaterally nephrectomized under anesthesia with a combination of halothane, nitrous oxide and oxygen. Twenty four hours later under anesthesia with Inactin (100 mg/kg), they were ganglion blocked (pentolinium tartrate; 19.2 mg/kg), and their systolic blood pressure and heart rate were measured before and after intravenous administration of captopril (2.5 mg/kg), NPP (20μl plasma equivalent) or purified β-FXIIa (300 ng/kg). Results: NPP raised the systolic blood pressure by 31±2 mmHg and heart rate by 19±2 bpm in sham-operated rats. Captopril caused systolic blood pressure and heart rate to increase significantly by 64±7 mmHg and 107±9 bpm, respectively in response to NPP. In bilateral nephrectomized rats, NPP raised systolic blood pressure by 57±6 mmHg and heart rate by 70±13 bpm in the absence of captopril, which were not significantly different from those (46±3 mmHg and 75±8 beats/min) in the presence of captopril. Conclusion: This study shows that the effects of NPP and β-fragment of factor XІІ on systolic blood pressure and heart rate are similar, suggestive of a functional relationship between them. The findings might suggest that the potentiation effect of captopril in sham-operated or bilaterally nephrectomized rats is primarily expressed via renal enzymes.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله A. Pejhan |


P.C. Papageorgiou |


D. Osmond |


نشانی اینترنتی http://ijms.sums.ac.ir/article_43358_f1cc59b5b1c8d9d133eda5e64991d1ea.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-1611548.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات