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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۸، صفحات ۹۵۶-۹۶۲
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عنوان انگلیسی The impact of Lactobacillus acidophilus on hepatic and colonic fibrosis induced by ethephon in a rat model
چکیده انگلیسی مقاله Objective(s): The study is aimed to elucidate the impact of antioxidant, anti-inflammatory and antifibrosis properties of Lactobacillus acidophilus (L. acidophilus) on liver and colon in ethephon treated rats through measuring Pro- inflammatory cytokines, oxidative stress index, lysosomal cathepsin-D enzyme activity and fibrosis markers.Materials and Methods: Rats divided into three groups; Group 1: distilled water control, Group 2: rats at day 16 from experiment beginning were orally received ethephon 50 mg/ kg BW in distilled water once daily for 60 days.  Group 3: rats were orally received L. acidophilus enriched diet 1% (w/w) for 15 days as prophylactic, then received both L. acidophilus enriched diet 1% (w/w) and ethephon 50 mg/kg BW for 60 days. Results: Ethephon exerts hepatic and colonic oxidative stress, inflammatory response and fibrosis through NF-κB activation. On contrary, L. acidophilus supplementation evokes hepatoprotective properties as revealed by decreased serum AST, ALT, γ -GT and increased IGF-1. L. acidophilus exerts antioxidant and anti-inflammatory properties as indicated by decreased TOS, OSI, TNF-α, IL-1β, cathepsins D activity, NF-κB expression and increased TAC, lysosomal membrane stability. L. acidophilus shows antifibrotic activity as demonstrated by down-regulation of TGF-β1, α-SMA, collagen expression. Conclusion: L. acidophilus possess antioxidant, anti -inflammatory and antifibrotic activity through inhibition of NF-kB.
کلیدواژه‌های انگلیسی مقاله Ethephon, Immunity, L. acidophilus, NF-κB, α-SMA
نویسندگان مقاله | Hoda I Bahr
Biochemistry Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt


| Rania Hamad
Pathology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt


| Shimaa A A Ismail
Clinical Pathology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt
نشانی اینترنتی http://ijbms.mums.ac.ir/article_13346.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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