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Avicenna Journal of Phytomedicine، جلد ۹، شماره ۴، صفحات ۳۷۴-۳۸۵
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis
چکیده انگلیسی مقاله Objective: The glucose-reducing effects of troxerutin was previously proven. This study was conducted to evaluate troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male rats. Materials and Methods: Fifty male Wistar rats were randomly classified into 5 groups as follows: control (C), troxerutin (T), diabetic (DM), troxerutin-treated DM (DT) and insulin-treated DM (DI). Testicular structure, apoptosis, lipid peroxidation and antioxidant activity, and spermatozoid parameters were assessed 4 weeks after initiation of the interventions. Results: The results revealed that diabetes caused testicular stereological changes and significantly increased blood glucose level, testicular MDA content and apoptosis but decreased insulin level, testicular GPX activity, and sperm parameters compared to controls (p Conclusion: Taken together, troxerutin, comparable to insulin, effectively improved DM-induced testicular dysfunction and sperm parameters in diabetic rats and these effects might be mediated through troxerutin's anti-apoptotic effects.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Afsaneh Qadiri
Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran.|Student research committee, Tabriz University of Medical Sciences, Tabriz, Iran


| Fariba Mirzaei Bavil
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


| Gholamreza Hamidian
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.


| Zohreh Zavvari Oskuye
Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Mahdi Ahmadi
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Hajar Oghbaei
Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Keivan Mehri
Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Amir Mansour Vatankhah
Drug applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


| Rana Keyhanmanesh
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
نشانی اینترنتی http://ajp.mums.ac.ir/article_12741.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-1645231.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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