این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۴۸، شماره ۷، صفحات ۱۲۹۲-۱۳۰۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
چکیده انگلیسی مقاله Abstract Background: We aimed to investigate the effect of probiotic VSL#3 on NF-κB and TNF-α in rats with colitis and the correlation with TLR4-NF-κB signal pathway. Methods: Sixty Sprague Dawley (SD) rats were divided into the control, model and therapy groups (n=20) according to the random number table. Rats in the model and therapy groups were modeled for colitis, and rats in the therapy group were intragastrically administered with probiotic VSL#3. The expression of TLR4 and NF-κB protein, and the levels of NF-κB, TLR4, and TNF-α mRNA in the colon tissue were detected. The concentration of TNF-α in the serum after modeling but before intragastric administration (T0), 3d (T1) and 7d after intragastric administration (T2) was detected. Results: The expression of TLR4 and NF-κB p65 protein, and the levels of TLR4, NF-κB, and TNF-α mRAN in the therapy group decreased (P < 0.001). At T0, T1, and T2, the concentration of TNF-α in the model and control groups increased (P < 0.001). TLR4 and NF-κB in the therapy group were positively correlated with TNF-α mRAN (P < 0.050).Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis. Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis.  
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Hui WANG
Department of Immunology, Qiqihar Medical University, Qiqihar 161000, P.R. China


| Shuhua LI
Department of Traditional Chinese Medicine, The First Hospital of Qiqihar, Qiqihar 161000, P.R. China


| Houzhong LI
Department of Pharmacology, Mudanjiang Medical University, Mudanjiang 157011, P.R. China


| Fengxia DU
Department of Pathogen Biology, Qiqihar Medical University, Qiqihar 161000, P.R. China


| Jie GUAN
Department of Immunology, Qiqihar Medical University, Qiqihar 161000, P.R. China


| Yanmin WU
Department of Immunology, Qiqihar Medical University, Qiqihar 161000, P.R. China
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/17589
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-1655062.pdf
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات