این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱۴، شماره ۲، صفحات ۱۶۵-۱۷۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله CD 10،Immunohistochemistry،Gleason،Gleason Grade group،Prostate Carcinomaو Prostate specific antigen،
عنوان انگلیسی Secondary Malignant Transformation of Giant Cell Tumor of Bone: Is It a Fate?
چکیده انگلیسی مقاله The malignant transformation of conventional giant cell tumor of bone (GCTOB) is rare and usually occurs with irradiation. Here we report two neglected cases of conventional GCTOB with spontaneous malignant transformation at 11 and 16 years after initial diagnosis. In the former case, the patient refused to receive any treatment following the incisional biopsy, and in the latter, the first recurrence that occurred 5 years after initial treatment, was neglected. Although rare, the occurrence of sarcomatous changes in these cases indicates that secondary malignant transformation may be part of the natural course of this tumor. In addition, in both cases, immunohistochemistry showed diffuse and strong p53 expression in the malignant tumor but not in the primary lesion. It suggests that p53 overexpression may play a key role in the malignant transformation of GCTOB and that investigating for p53 expression in recurred lesions may help in predicting cases of giant cell tumor, prone to malignant transformation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله Sajjadeh Movahedinia |
MD-MPH, AP/CP, Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Department of Pathology and Laboratory Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

Tina Shooshtarizadeh |
MD, AP/CP, Department of Pathology, Shafa Yahyaean Orthopedics Hospital, Iran University of Medical Sciences, Tehran, Iran

Hassan Mostafavi |
MD, Department of Radiology, Iran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://ijp.iranpath.org/article_35717_b2ec615155c13b333f5bcc9f4bfee653.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-1667974.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات