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Iranian Journal of Biotechnology، جلد ۱۷، شماره ۲، صفحات ۷۹-۸۸
عنوان فارسی Integrin Beta-۳ Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease
چکیده فارسی مقاله Background: Contradictory results have been obtained regarding the role of integrin, beta 3 (ITGB3) gene polymorphisms in occurrence of myocardial infarction (MI).
Objectives: We aimed to assess the association between 1565C/T polymorphism of ITGB3 gene and increased risk for acute MI in patients with premature coronary artery disease (CAD).
Material and Methods: Our study included 1000 premature CAD patients that classified into two groups with history of MI (n = 461) and without of MI (n = 539). The polymorphism variants in 10% of samples were determined by PCR-RFLP technique and genotyping of the polymorphism in all subjects was conducted by High Resolution Melting method. Given the two conditions of patients residing in Tehran and also faced with their first episode of MI, 640 out of 1000 study samples that had been previously followed-up were assessed in a retrospective cohort phase regarding long-term major adverse cardiac events (MACE).
Results: There was no significant difference in the frequency of 1565C/T polymorphism between the MI and non-MI groups. The frequency of wild genotype was 69.2% and 72.2%, the frequency of homozygous genotype was 21.3% and 18.4%, and the frequency of mutant genotype was 9.5% and 9.5%, respectively (P = 0.505). No significant difference was also found in total-MACE free survival rate between the patients with different genotypes of 1565C/T polymorphism in both MI and non-MI group.
Conclusions: The carriage of the 1565C/T polymorphism of ITGB3 gene seems unlikely to be a significant risk factor for the development of MI in Iranian patients with premature CAD.
کلیدواژه‌های فارسی مقاله Coronary Artery Disease،، Myocardial Infarction، Genetics،، Atherosclerosis،
عنوان انگلیسی Integrin Beta-3 Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease
چکیده انگلیسی مقاله Background: Contradictory results have been obtained regarding the role of integrin, beta 3 (ITGB3) gene polymorphisms in occurrence of myocardial infarction (MI).
Objectives: We aimed to assess the association between 1565C/T polymorphism of ITGB3 gene and increased risk for acute MI in patients with premature coronary artery disease (CAD).
Material and Methods: Our study included 1000 premature CAD patients that classified into two groups with history of MI (n = 461) and without of MI (n = 539). The polymorphism variants in 10% of samples were determined by PCR-RFLP technique and genotyping of the polymorphism in all subjects was conducted by High Resolution Melting method. Given the two conditions of patients residing in Tehran and also faced with their first episode of MI, 640 out of 1000 study samples that had been previously followed-up were assessed in a retrospective cohort phase regarding long-term major adverse cardiac events (MACE).
Results: There was no significant difference in the frequency of 1565C/T polymorphism between the MI and non-MI groups. The frequency of wild genotype was 69.2% and 72.2%, the frequency of homozygous genotype was 21.3% and 18.4%, and the frequency of mutant genotype was 9.5% and 9.5%, respectively (P = 0.505). No significant difference was also found in total-MACE free survival rate between the patients with different genotypes of 1565C/T polymorphism in both MI and non-MI group.
Conclusions: The carriage of the 1565C/T polymorphism of ITGB3 gene seems unlikely to be a significant risk factor for the development of MI in Iranian patients with premature CAD.
کلیدواژه‌های انگلیسی مقاله Coronary Artery Disease, Myocardial Infarction, Genetics, Atherosclerosis
نویسندگان مقاله Mehrdad Sheikhvatan |
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Ali boroumand |
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Mehrdad Behmanesh |
Tarbiat Modarres University, Tehran, Iran

Shayan Ziaee |
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Sara Cheraghee |
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://www.ijbiotech.com/article_85173_f60a721840a68b847a5374b90d107dec.pdf
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