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Journal of Pharmaceutical Care، جلد ۶، شماره ۳-۴، صفحات ۴۴-۵۱
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عنوان انگلیسی Statin Utilization Patterns among Type 2 Diabetes Mellitus Patients with High Cardiovascular Disease Risks in Ethiopia
چکیده انگلیسی مقاله Background: Use of statin therapy in patients with type 2 diabetes mellitus has been recommended by most clinical guidelines. Cardiovascular disease is a leading cause of morbidity and mortality among type 2 diabetes mellitus patients. It has been proved that statins are effective for primary or secondary cardiovascular disease prophylaxis. Objective: The main objective of the study was to assess pattern of statin use among type 2 diabetes mellitus patients with high risk of cardiovascular diseases at Jimma University Medical Center. Methods: Hospital based cross sectional study was conducted among type 2 diabetes mellitus ambulatory patients based on the inclusion criteria. Patient specific data was collected using structured data collection tool. Data was analyzed using statistical software package, SPSS version 20.0. To identify the independent predictors of statin use, multiple stepwise backward logistic regression analysis was done. Statistical significance was considered at p-value < 0.05. Patient’s written informed consent was obtained after explaining the purpose of the study. Patients were informed about confidentiality of the information obtained. Results: From a total of 150 study participants, 93(62%) of them were males. Majority of the patient, 112(74.7%), were between age of 40-64 years, with mean ± SD   of 46.65±19.61 years.  About 55(36.67%) of participants were on statin therapy for treatment and prophylaxis (primary& secondary prophylaxis).  Uncontrolled blood sugar (COR=1.643; 95% CI: 1.291–2.077; P=0.056), smoking (COR=1.102; 95% CI: 0.913–1.321; P=0.026) & long time with diabetes (COR=1.067; 95% CI: 1.007-14.659; P=0.021) showed statistically significant association with statin use.  Age between 65 to 74 years (AOR = 3.006; 95% CI: 1.440–6.277; P = 0.003), presence of co morbidity (AOR 4.486; 95% CI: 2.080–9.673; P< 0.001) and elevated blood cholesterol (AOR = 1. 422; 95% CI: 1.244–1.622; P = 0.033), living with DM for more than 10 years (AOR=2.45; 95% CI: 1.524- 3.891; p=0.027) and uncontrolled blood sugar (AOR=2.127; 95% CI: 1.833–2.457; p=0.0241) were independent predictor of statin use. Conclusion: Despite contemporary recommendations that all people with diabetes should be treated with statins, majority of our patients with T2DM were not receiving statins. Further interventions to improve statin use should be considered for these high risk patients.
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نویسندگان مقاله | Tsegaye Melaku
Jimma University


| Yordanos Solomon
Jimma University


| Legese Chelkeba
Jimma University
نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/249
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