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Basic and Clinical Neuroscience، جلد ۱۰، شماره ۴، صفحات ۳۱۳-۳۲۲
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عنوان انگلیسی Comparing the Antinociceptive Effects of Methamphetamine, Buprenorphine, or Both After Chronic Treatment and Withdrawal in Male Rats
چکیده انگلیسی مقاله Introduction: Methamphetamine (Meth) and Buprenorphine (BUP) modulate pain perception. However, the antinociceptive effects of their interactions, which affect through different systems, are unclear in rats. This study aimed to compare the analgesic effects of Meth, BUP, and their coadministration, as well as the effect of withdrawal from these substances on nociception in male rats. Methods: In this experiment, 40 male Wistar rats (weight: 250-300 g) were categorized into four groups: control, Meth, BUP, or BUP+Meth. After seven days of treatments, the antinociceptive effects were assessed using the hot plate and the tail flick tests. The differences among the groups were analyzed with ANOVA and Tukey's post hoc tests. P values less than 0.05 were considered significant. Results: Meth and BUP increased the reaction times during the hot plate and tail flick tests. The combination of Meth and BUP increased reaction time more than Meth or BUP alone.  Conclusion: The significantly high reaction times in rats treated with Meth and BUP indicate that these substances have antinociceptive effects. In addition, Meth enhanced the antinociceptive effects of BUP. These synergistic effects might occur through the dopaminergic, serotonergic, and or adrenergic systems.
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نویسندگان مقاله | Farshid Etaee
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Arezoo Rezvani-Kamran
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.


| Mohammad Taheri
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.


| Ghazaleh Omidi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.


| Parisa Hasanein
Department of Biology, School of Sciences, University of Zabol, Zabol, Iran.


| Alireza Komaki
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-290-5&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-1733026.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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