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Basic and Clinical Neuroscience، جلد ۱۰، شماره ۴، صفحات ۳۳۳-۳۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of Muscle Graft With Nerve Growth Factor and Laminin on Sciatic Nerve Repair in Rats
چکیده انگلیسی مقاله Introduction: Peripheral nerve injury is one of the most common damages that lead to physical disability. Considering the similarity between the coatings of skeletal muscles and nerve fibers, we conducted this research to determine the effect of muscle graft with Nerve Growth Factor (NGF) and Laminin (L) on nerve repair.  Methods: We cut a 10-mm length of the sciatic nerve from 42 female Wistar rats (Weight: 200±250 g) and equally divided the rats into three groups. In the muscle graft+NGF+laminin group, the degenerated skeletal muscle was sutured with proximal and distal ends of the transected sciatic nerve. Then, NGF (100 ng) and laminin (1.28 mg/mL) were injected into the muscle graft. In the muscle graft group, normal saline was injected into the muscle graft. In the control group, 10 mm of the sciatic nerve was removed without any treatment. Functional recovery was assessed based on Sciatic Functional Index (SFI). Also, tracing motor neurons and histological studies were performed to evaluate nerve repair. The obtained data were analyzed by ANOVA test.  Results: The Mean±SD SFI value significantly increased in the muscle graft+NGF+laminin (-76.6±2.9) and muscle graft (-82.1±3.5) groups 60 days after the injury compared to the control group. The Mean±SD number of labeled motor neurons significantly increased in the muscle graft+NGF+laminin (78.6±3.1) and muscle graft (61.3±6.1) groups compared to the control group (P< 0.001). The mean number of myelinated axons in the distal segments of the muscle graft+NGF+laminin increased significantly compared to the muscle graft group. Conclusion: These findings suggest that muscle graft followed by NGF and laminin administration have therapeutic effects on nerve repair.
کلیدواژه‌های انگلیسی مقاله Peripheral nerve, Muscle graft, Growth factor, Laminin, Rats
نویسندگان مقاله | Mehrzad Jafaripoor
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.


| Hamdollah Delaviz
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.


| Somayeh Torabi
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.


| Jamshid Mohammadi
Herbal Medicine Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.


| Izadpanah Gheitasi
Herbal Medicine Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-690-2&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-1733028.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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