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Basic and Clinical Neuroscience، جلد ۱۰، شماره ۴، صفحات ۳۶۳-۳۷۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Introducing Genes With Significant Role in Migraine: An Interactomic Approach
چکیده انگلیسی مقاله Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers.  Methods: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened.   Results: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes. Conclusion: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine. 
کلیدواژه‌های انگلیسی مقاله Migraine disorders, Protein interaction maps, Genes
نویسندگان مقاله | Mona Zamanian-Azodi
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mostafa Rezaei-Tavirani
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Reza Mahmoud Robati
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-941-5&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-1733031.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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