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Basic and Clinical Neuroscience، جلد ۱۰، شماره ۴، صفحات ۳۹۳-۴۰۰
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عنوان انگلیسی Effects of Dextromethorphan on Depressive- and Cognitive-Associated Behaviors: A Sexually Dimorphic Study
چکیده انگلیسی مقاله Introduction: We investigated the sexually dimorphic effects of Dextromethorphan (DM) on cognitive and depression-like behaviors as well as on hippocampal histology in rats following acute administration. Methods: Wistar rats of both sexes were treated with 25 or 50 mg/kg of DM for 7 days via intraperitoneal injection. At the end of the administration, behavioral studies were performed on the Tail Suspension Test (TST) for depressive-like behaviors and the Y-maze for cognitive behaviors. The rats' brains were excised and processed for routine histological analysis.  Results: Our results showed that DM significantly increased (P< 0.05) immobility time in the TST in male rats but not female ones, and decreased percentage alternation (P< 0.001) on the Y-maze in both male and female rats. Histological analysis revealed no morphological changes in the hippocampus following DM treatment.  Conclusion: DM impairs cognitive functions in both male and female rats without histologic defects in the hippocampus. However, the induced depressive-like behaviors following DM administration may be sexually dependent.
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نویسندگان مقاله | Omamuyovwi Meashack Ijomone
Department of Anatomical Sciences, School of Health and Health Technology, Federal University of Technology Akure, Nigeria.; Department of Anatomy and Forensic Anthropology, Faculty of Basic Medical Sciences, Cross River University of Technology, Calabar, Nigeria.


| Ifechukwude Joachim Biose
Department of Anatomy and Forensic Anthropology, Faculty of Basic Medical Sciences, Cross River University of Technology, Calabar, Nigeria.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1389-1&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-1733034.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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