این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Basic and Clinical Neuroscience، جلد ۱۰، شماره ۴، صفحات ۴۰۱-۴۰۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Introducing Critical Pain-related Genes: A System Biology Approach
چکیده انگلیسی مقاله Introduction: Pain is valuable in diagnosis and also warning of the patients. Many molecular reagents are introduced which are related to pain. In this research, the pain-related genes are screened to identify the critical ones.  Methods: First, the pain-related genes were pulling out from the STRING database, and Cytoscape software was used to make the interactome unit. Then the central genes and their neighbors were analyzed. Finally, the genes were clustered, and the essential genes were introduced. Results: After analyzing 159 genes of the network, FOS, IL6, TNF, TAC1, IL8, and KNG1 were identified as the essential genes. Further analysis revealed that 88 genes are directly connected to the central genes. More resolution led to ignoring TNF and IL8 and considering SCN-alpha and PAICS as additional critical nodes.  Conclusion: Six critical genes related to pain were identified. They can be potentially considered as new drug targets. Further investigation is required to introduce the central genes as a pain killer.
کلیدواژه‌های انگلیسی مقاله Drug, Database, Pain, Gene, Network
نویسندگان مقاله | Mostafa Rezaei Tavirani
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Sina Rezaei Tavirani
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Mohammad-Mahdi Zadeh-Esmaeel
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Nayeb Ali Ahmadi
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1483-1&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-1733035.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات