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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۹، صفحات ۱۰۱۰-۱۰۱۵
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عنوان انگلیسی Early oleate deficiency leads to severe defects in fetal rat liver development
چکیده انگلیسی مقاله Objective(s): Oleate can be produced through de novo synthesis, which contributes to biological processes and signaling pathways. However, the role of this non-essential fatty acid in hepatic development remains unclear. The current study aimed to evaluate the influence of early oleate deficiency induced by the inhibitor of de novo oleate synthesis MF-438 on fetal rat liver development.Materials and Methods: Female Wistar rats with an average weight of 200±20 g were subjected to this study. After mating, pregnant rats were divided into three groups and gavaged with the vehicle, MF 438 or MF-438 plus oleate from day 3 of pregnancy for five days. Obtained fetuses were sacrificed and the liver tissues were retrieved. Hepatic morphological index, biochemical markers, and gene expression of hepatic development markers were analyzed using Hematoxylin-Eosine, spectrometry, and real-time PCR techniques, respectively.Results: Relatively, deficient morphological indices and hepatic maturation markers were observed in fetus livers of the inhibitor-treated group. In comparison to the other two groups, total hepatic protein and glycogen content were increased with treatment of MF-438 plus oleate. Hepatocyte nuclear factor 1α, alpha fetoprotein, albumin, and cytochrome P450 gene expression were also significantly increased in the group treated with both MF-438 and oleate.Conclusion: Our data indicate that oleate availability during early embryo development is linked with fetal rat liver development.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Fatemeh Mohammadzadeh
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Alireza Alihemmati
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Abbas Pirpour Tazehkand
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Masoud Darabi
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Amir Mehdizadeh
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|Comprehensive Health Lab, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_13533.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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