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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۹، صفحات ۱۰۴۴-۱۰۴۹
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عنوان انگلیسی Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study
چکیده انگلیسی مقاله Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify discriminative metabolites between two groups. Results: A set of metabolites were detected, including propionic acid, putrescine, acetic acid, succinic acid, tyrosine, lactic acid, butyric acid, pyruvic acid, 4-pyridoxic acid and 4-hydroxybenzoic acid, which in combination with one another could accurately distinguish patients from healthy controls. Our results clearly demonstrated altered metabolites are involved in nine metabolic pathways. Conclusion: Metabolomics has the potential to be considered as a novel clinical tool for hepatitis B diagnosis while contributing to a comprehensive understanding of disease mechanisms.
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نویسندگان مقاله | Kambiz Gilany
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran|Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran


| Ashraf Mohamadkhani
Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Saeed Chashmniam
Department of Chemistry, Sharif University of Technology, Tehran, Iran


| Parisa Shahnazari
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran


| Mehdi Amini
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran


| Babak Arjmand
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran


| Reza Malekzadeh
Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Bibi Fatemeh Nobakht Motlagh Ghoochani
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran|Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_13244.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1759435.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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