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Bulletin of Emergency and Trauma، جلد ۷، شماره Issue ۳، صفحات ۲۸۴-۲۹۱
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عنوان انگلیسی Effects of Chitosan/Nano Selenium Biofilm on Infected Wound Healing in Rats; An Experimental Study
چکیده انگلیسی مقاله Objective: The present study was aimed at assessment of effect of application of Chitosan/Nano Selenium biofilm on infected wound healing in ratsMethods: Sixty-eight male Wistar rats were randomized into four groups of 17 animals each. In group I (Normal) the wounds were created with no infection. In group II (MRSA), the wounds were infected with methicillin resistant Staphylococcus aureus (MRSA). In group III (MRSA/CHIT), animals with infected wounds were dressed with chitosan biofilm only. In group IV (MRSA/CHIT/NS), animals with infected wounds were dressed with Chitosan/Nano Selenium biofilm.Results: There were significant differences in comparisons of group IV and other groups, particularly in terms of cellular infiltration and neovascularization. During the study period, scores for neovascularization was significantly higher in group IV rats than other groups (P< 0.05). Polymorphonuclear (PMN) and mononuclear (MNC) cell count and fibroblast cell proliferation in group IV were significantly higher than those of other experimental groups (P< 0.05)Conclusion: Chitosan/Nano Selenium biofilm resulted in significant improvement in histopathological indices in full thickness infected wound healing.
کلیدواژه‌های انگلیسی مقاله Infected wound,Chitosan/Nano Selenium,Biofilm,Rat
نویسندگان مقاله Abolfazl Abbaszadeh |
Department of Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Akram Tehmasebi-Foolad |
Student research committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Asghar Rajabzadeh |
Department of Anatomical Sciences, Faculty of Medicine, Lorestan University of Medical Sciences, Kharamabad, Iran

Nasim Beigi-Brojeni |
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Leila Zarei |
Department of Anatomical Sciences, Faculty of Medicine, Lorestan University of Medical Sciences, Kharamabad, Iran

نشانی اینترنتی http://beat.sums.ac.ir/article_45374_b58419d608e0bc0b97b504d58d8a7891.pdf
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