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Journal of Craniomaxillofacial Research، جلد ۶، شماره ۱، صفحات ۳۴-۳۸
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عنوان انگلیسی Assessing VEGF mRNA and miR-494 expression in peripheral blood collected from patients suffering from oral squamous cell carcinoma
چکیده انگلیسی مقاله Introduction: Oral squamous cell carcinoma accounts for 2% of all cancers and also is one of  the top 10 causes of death in humans. The goal of this article is to assess changes of VEGF mRNA and miR-494 expression. Materials and Methods: We chose 30 patients with OSCC and 30 healthy people (as a controlled group) and assess the rate of VEGF mRNA and miR-494 expression in peripheral blood with real-time PCR technique. Findings: VEGF mRNA marker was positive in 24 out of 30 patients. Also, miR-494 was positive in 20 out of 30 patients. Results: Overall based on this article’s findings, results could count as a diagnostic screening test for OSCC  detection in early steps of cancer. Keywords: Oral squamous cell carcinoma; Early diagnosis; VEGF mRNA; miR-494.
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نویسندگان مقاله | Maryam Masoum khani
Department of Cell and Molecular Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.


| Abdolreza Mohamadnia
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Farzaneh Hosseini
Department of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, Iran.


| Parisa Bayat
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Naghmeh Bahrami
Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://jcr.tums.ac.ir/index.php/jcr/article/view/290
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