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Basic and Clinical Cancer Research، جلد ۱۱، شماره ۳، صفحات ۳۱۸-۳۱۸
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عنوان انگلیسی The Candida albicans activated splenocytes promote strong immune responses in a murine model of breast cancer
چکیده انگلیسی مقاله Introduction: The potential of Candida albicans to modulate antigen presenting cells maturation has been already documented. Dendritic cells are critical modulators in the orchestration of adaptive immune responses alongside myeloid subtypes, which play important role in presentation of antigens to T cells. The aim of this study was to evaluate the efficacy of activated splenocytes by the extract of heated 4T1 cells and yeast form of C. albicans against breast cancer growth in vivo‏. Methods: 4T1 cells were subcutaneously injected into the left flanks of female BALB/c mice. At a time when palpable tumors had developed, experimental groups were immunized twice at one-week interim with either activated splenocytes with the extract of heated 4T1 or the killed preparation of yeast form of C. albicans or combined killed preparation of C. albicans and 4T1. One week after the second injection, one-half of mice were euthanized to investigate the immune response profile. Results: Administration of activated splenocytes with combined protocol caused a favorable survival curve and slower rates of tumor development compared to other tumor-bearing mice. Moreover, combined therapy significantly increased the secretion of IFN-γ, respiratory burst and nitric oxide production, conversely, diminished the secretion of IL-4, IL-10 and TGF-β in splenocyte population. Conclusions: As murine 4T1 cell line is similar to the final stage of human breast carcinoma, we postulate that activated splenocytes with the extract of heated 4T1 cells and yeast form of C. albicans can roughly reduce tumor development in tumor-bearing mice.
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نویسندگان مقاله | Siavash Mashhouri
Urmia University


| Erfan Yarahmadi
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University


| Seyyed Meysam Abtahi Froushani
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University
نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/318
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