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Journal of Pharmaceutical Care، جلد ۷، شماره ۱-۲، صفحات ۱۴-۲۰
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عنوان انگلیسی Rituximab Utilization Evaluation with Focused on Available Evidence for Off-Labeled Indications
چکیده انگلیسی مقاله Abstract Objectives: To investigate the on-labeled and off-labeled indications of rituximab according to available evidence and the cost in our center. Methods: This retrospective cross-sectional study was conducted between August 2016 and August 2017 at a teaching hospital affiliated to Iran University of Medical Sciences, Tehran, Iran. Patients’ demographic data and disease, indication for rituximab use, its dosage and treatment regimen and previous and concurrent treatments was assessed. The collected data were compared with the current criteria for the pattern of rituximab use. The last version of Lexicomp® acquired by Wolters Kluwer was used as the reference for on-labeled and off-labeled indications of the prescribed drug and its dosage. Level of evidences for applied indications and cost has also been evaluated. Results: A total of 85 patients received rituximab during the study period. The most frequent reasons for rituximab prescription were: multiple sclerosis (50.58%), systemic sclerosis (10.58%), rheumatoid arthritis (7.05%) and Idiopathic inflammatory myopathies (4.70%). Rituximab was used in 8 (9.4%) cases according to on-labeled indications. There was level C evidence for rituximab use in off-labeled indications in 47 (55.29%) cases according to available evidences which accounts for the highest calculated cost. Conclusion: Based on our results, rituximab was frequently administrated for off-labeled indications most of which are not supported by established levels of evidence. Strong evidence is necessary for decision making regarding its effectiveness. Keywords: Rituximab; Drug Utilization Evaluation; Multiple Sclerosis
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نویسندگان مقاله | Sohrab Aghabeigi
Department of Internal Medicine, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran.


| Maryam Farasatinasab
Department of Clinical Pharmacy, Firoozgar Clinical Research Development Center (FCRDC), School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran


| Atefeh Amouzegar
Department of Nephrology, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran.


| Soodeh Ramezaninejad
Department of Internal Medicine, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran.


| Behrooz Ghanbari
Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran.


| Nashmin Pakdaman
Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran


| Mohammad Reza Motamed
Department of Neurology, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran


| Simin Almasi
Department of Rheumatology, Rheumatology Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran


| Nader Rezaie
Department of Pulmonology, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran.


| Somayyeh Nasiripour
Department of Clinical Pharmacy, Rasul-e Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran


| Forough Sabzghabaei


| Ali Basi


نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/260
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