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The Archives of Bone and Joint Surgery، جلد ۷، شماره ۵، صفحات ۰-۰
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کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effectiveness of Platelet-Rich Plasma Based on Gene Expression in Knee Osteoarthritis
چکیده انگلیسی مقاله Object: Intra-articular injection of PRP is an effective method for treatment of patients with knee joint osteoarthritis (OA). The aim of this study was to assess the effects of PRP injection on gene expression in knee OA. Material and methods: in this study 30 patients affected by knee OA were evaluated for KOOS and ICOAP questionnaire. The expression of expression of IGF-1, HIF-1, COMP and BMP2 were compared in patient before and 1 month after PRP injection. Results: Mean expression of IGF-1, HIF-1, COMP and BMP2 were higher in subjects with PRP injection, However, only up-regulation of IGF-1 was statistically significant (P< 007). The mean total KOOS and ICOAP revealed significant change (P< 0.01). Conclusion: These data found that intra-articular injections of PRP can improved the pain, stiffness and quality of life in knee OA by promoting IGF-1 expression.
کلیدواژه‌های انگلیسی مقاله platelet-rich plasma, Osteoarthritis, IGF-1
نویسندگان مقاله | Mohammad Mousaei Ghasroldasht
Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran


| Amir Moayednia
Shahid sadooghi Hospital, isfahan, iran


| Mostafa Shahrezaee
Department of Orthopedic Surgery, AJA University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://abjs.mums.ac.ir/article_12878.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده RESEARCH PAPER
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