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Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۴، صفحات ۲۹۳-۳۰۷
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عنوان انگلیسی Preparation and optimization of polymeric micelles as an oral drug delivery system for deferoxamine mesylate: in vitro and ex vivo studies
چکیده انگلیسی مقاله Deferoxamine mesylate (DFO) is administered as a slow subcutaneous or intravenous infusion due to its poor oral bioavailability and lack of dose proportionality. The aim of the present study was to prepare and optimize polymeric micelles containing DFO, as an oral drug delivery system for increasing permeability and oral bioavailability. Based on a full factorial design with three variables in two levels, eight polymeric micelle formulations were made using film hydration method. Two polymers including 0.1% of carbomer 934 and Poloxamer ® P 407 and two blends of surfactant + co-surfactant including1 and 2 fold of critical micelle concentration of Labrafil ® + Labrasol ® and Tween 80 + Span 20 were used to prepare polymeric micelles. The effect of variables on particle size (PS), entrapment efficiency (EE), drug release, thermal behavior, in vitro iron bonding and ex vivo rat intestinal permeability were evaluated. The PS of polymeric micelles was less than 83 nm that showed 80% EE with continuous drug release pattern. The change in type of polymer from carbomer to Ploxamer ® significantly increased drug release. All polymeric micelles increased the iron-bonding ability of DFO compared to control. This could be due to surfactants that can play an important role in this ability. Polymeric micelles increased drug permeability through intestine more than 2.5 folds compared to control mainly affected by polymer type.Optimized polymeric micelle consists of Tween 80 and Span 20 with 1.35 folds of critical micelle concentration and Poloxamer ® demonstrated 97.32% iron bonding and a 3-fold increase in permeation through the rat intestine compared with control.
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نویسندگان مقاله | Anayatollah Salimi
1School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran. 2Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran


| Behzad Sharif Makhmal Zadeh
1School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran.


| Moloud Kazemi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1908
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1870953.pdf
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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