این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research in Pharmaceutical Sciences، جلد ۱۴، شماره ۴، صفحات ۳۲۹-۳۳۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Sesquiterpene lactones from shoot culture of Artemisia aucheri with cytotoxicity against prostate and breast cancer cells
چکیده انگلیسی مقاله Plant tissue culture is used to grow plant cells, tissues, or organs under sterile and determined conditions on culture media. It is alternative to traditional vegetative propagation, and is applied as an effective technology for the production of valuable secondary metabolites. The Artemisia aucheri ( A. aucheri ) was obtained from shoot culture grown on MS (Murashige and Skoog 1962) medium. Shade-dried aerial parts of in vitro grown A. aucheri (50 g) were extracted with dichloromethane-acetone (90:10). The extract was submitted for isolation to sephadex gel chromatography and preparative thin layer chromatography, which resulted in identification of one known eudesmanolide named artemin or 2,5-dihydroxy-12, 6-eudesmanolide-4(15)-en for the first time in this plant. In cell cytotoxicity test, artemin showed cytotoxic activity against DU-145,LNCaP prostate cancer, and MCF-7 breast cancer cells with IC 50 values of 82.2 ± 5.6, 89.1 ± 6.3 and 111.5 ± 6.7 μM , respectively. Artemin was more active against prostate cancer cells with approximately same cytotoxicity against LNCaP androstane dependent cells and DU 145 which is androstane independent.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Jalil Abbaspour
1Department of Biology, Faculty of Science, University of Isfahan, Isfahan, I.R. Iran.


| Ali Akbar Ehsanpour
2Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Mahmoud Aghaei
3Department of Pharmacognosy, Isfahan Pharmaceutical Sciences Research center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. 4National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS 38655, USA.


| Mustafa Ghanadian


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1912
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1870956.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات