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International Journal of Radiation Research، جلد ۱۴، شماره ۲، صفحات ۹۱-۹۸
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عنوان انگلیسی Percutaneous microwave ablation of thyroid nodules: efficacy evaluation with 99m Tc - pertechnetate and 99mTc-MIBI functional imaging
چکیده انگلیسی مقاله Background: Local ablative treatments play an important role for patients who cannot be treated surgically. Radiofrequency ablation is a well-established alternative to surgical treatment of thyroid nodules, however it also has disadvantages. Microwave ablation (MWA) is a new minimally invasive treatment promising several improvements. The aim of this retrospective study was to evaluate the effects of microwave ablation on thyroid nodules by 99mTc-pertechnetate and 99mTc-MIBI scintigraphy. Materials and Methods: 30 patients with overall 40 nodules were treated. For the ablation of thyroid nodules, a microwave generator working with frequencies from 902 to 928 MHz was used. The ablation time ranged between 120 and 300 seconds per ablation zone. The target temperatures ranged between 60-80 °C. Pre- and post- interventional, the radionuclide uptake was determined using a thyroid specific scintillation camera. For 27 cold nodules 99mTc-MIBI was used for evaluation; 13 indifferent nodules were measured with 99mTc-pertechnetate. Results: The relative change of uptake was detected as a quotient of pre- and post- therapeutic uptake. The statistical analysis of scintigraphy data proved the efficacy of microwave ablation. 99mTc-pertechnetate scintigraphy showed an uptake reduction of 39% (range 9 to 85%). 99mTc-MIBI imaging showed a median reduction of 40% (p< 0.01) (range 7 to 100%). Conclusion: The determined results show the effectiveness of MWA as a treatment option for benign thyroid nodules. With functional scintigraphy a significant activity decrease could be detected in the ablation zone; hence a verification of affectivity was possible after a short period of time.
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نویسندگان مقاله k heck | k. heck
department of nuclear medicine, frankfurt university hospital, frankfurt, germany


y korkusuz | y. korkusuz
department of nuclear medicine, frankfurt university hospital, frankfurt, germany


c happel | c. happel
department of nuclear medicine, frankfurt university hospital, frankfurt, germany


f grünwald | f grünwald
department of nuclear medicine, frankfurt university hospital, frankfurt, germany


h korkusuz | h. korkusuz
department of nuclear medicine, frankfurt university hospital, frankfurt, germany
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-603&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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