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International Journal of Radiation Research، جلد ۱۴، شماره ۲، صفحات ۱۱۹-۱۲۵
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عنوان انگلیسی Evaluating the effect of Zinc Oxide nanoparticles doped with Gadolinium on dose enhancement factor by PRESAGE dosimeter
چکیده انگلیسی مقاله Background: New treatment modalities are developed with the aim of escalating tumor absorbed dose and simultaneously sparing the normal structures. The use of nanotechnology in cancer treatment offers some possibilities including destroying cancer tumors with minimal damage to healthy tissues. Zinc Oxide nanoparticles (ZnO NPs) are wide band gap semiconductors and seem to have a good effect on increasing the absorbed dose of target volume especially when doped with a high Z element. The aim of this study was to evaluate the effect of ZnO NPs doped with Gadolinium (Gd) on dose enhancement factor by 6MV photon beam irradiation. Materials and Methods: Various concentrations of ZnO NPs doped with 5% Gd were incorporated into PRESAGE composition, the 3D chemical dosimeter. Then by using a UV-Vis spectrophotometer optical density changes and also dose enhancement factor (DEF) were determined. Results: The results of this study showed that by incorporating 500, 1000, 3000 and 4000 µg/ml ZnO NPs doped with Gd into PRESAGE structure the dose enhancement factor of about 1.57, 1.69, 1.78 and 1.82 in a 15 ×15 cm2 field size could be found, respectively. Conclusion: The results of this study showed that ZnO NPs doped with Gd could be considered as new compound for increasing the absorbed dose.
کلیدواژه‌های انگلیسی مقاله Zinc Oxide, Gadolinium, Nanoparticle, PRESAGE, DEF
نویسندگان مقاله n بنایی | n. banaee
department of engineering, science and research branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

حسینعلی ندایی | h a nedaie
radiotherapy oncology department, cancer research center, cancer institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علیرضا شیرازی | a r shirazi
department of medical physics and biomedical engineering, faculty of medicine and radiation oncology research centre, cancer institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علیرضا زیرک | a r zirak
laser and optics research school, nstri, tehran, iran


s سجادی | s. sadjadi
nuclear science and technology research institute, tehran, iran
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-607&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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