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International Journal of Radiation Research، جلد ۱۳، شماره ۴، صفحات ۳۰۵-۳۱۶
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عنوان انگلیسی Nano selenium-lovastatin mixture modulate inflammatory cascade in arthritic irradiated model
چکیده انگلیسی مقاله Background: The development of nanotechnology has been a boon to mankind as its significance paved the way for several applications in therapeutics. This study was to evaluate the anti-arthritic capability of nano Selenium-lovastatin mixture (Lov-Se) against inflammatory cascade in arthritic irradiated rats. Materials and Methods: Animal model of Arthritis was organized by subcutaneous injection of Complete Freund’s adjuvant; CFA. Rats were exposed to γ-radiation (2Gy every 3 days up to total dose of 8 Gy). Lov-Se (1ml ≈ 20 mg kg−1 day−1Lov and 0.1 mg kg−1 day−1Se) was administrated by daily oral injection. The antioxidant parameters (heart glutathione peroxides; GSH-Px, catalase; CAT, superoxide dismutase; SOD, xanthine dehydrogenase; XDH, reduced glutathione; GSH and blood selenium; Se), oxidant markers (heart Xanthine oxidase; XO, Nitric oxide; NO, protein carbonyls and thiobarbituric acid reactive substances; TBARS) and the inflammatory molecules (serum tumor necrosis factor-alpha TNF-α, C-reactive protein; CRP and rheumatoid factor; RF) were determined. Results: The arthritic and arthritic irradiated rats were displayed augment oxidative stress, inflammatory cascade and impaired antioxidant status compared to control. Conclusion: The data revealed that Lov-Se administration ameliorate oxidative, antioxidants parameters as well as inflammatory factors. The prolonged administration of Lov-Se mixture in appropriate concentration could exert a considerable systemic anti-inflammatory action through adjustment of red-ox tone and the integration of XDH/XO ratio.
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نویسندگان مقاله خالد sh azab | khaled sh azab
radiation biology department, atomic energy authority, cairo, egypt


نورمحمد thabet | n m thabet
drug radiation research department, national center for radiation research and technology, atomic energy authority, cairo, egypt


a r b abdel غفار | a r b abdel ghaffar
biochemistry department, faculty of science, ain shams university, cairo, egypt


a عثمان | a. osman
biochemistry department, faculty of science, ain shams university, cairo, egypt


علی el batal | a i el batal
drug radiation research department, national center for radiation research and technology, atomic energy authority, cairo, egypt
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-577&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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