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International Journal of Radiation Research، جلد ۱۳، شماره ۴، صفحات ۳۱۷-۳۲۴
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عنوان انگلیسی Radiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostine
چکیده انگلیسی مقاله Background: The aim of the study was to compare the radioprotective efficacy in the kidney of L-carnitine to that of amifostine. Materials and Methods: Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradiation alone); Group 3 (amifostine plus irradiation); and Group 4 (L-carnitine before irradiation). The rats in Groups 2, 3, and 4 were irradiated individually with a single dose of 20 Gy to whole abdomen. L-carnitine (300 mg/kg) or amifostine (200 mg/kg) was administered 30 minutes before irradiation. Euthanasia was performed 5 days after irradiation, and kidneys were evaluated histopathologically. Results: Dilatation of Bowman’s capsule, congestion of blood vessels, and tubular epithelial degeneration were significantly different among the groups (p < 0.05). Pretreatment with both L-carnitine and amifostine reduced the radiation-induced dilatation of Bowman’s capsule (p < 0.05), congestion of blood vessels (p < 0.05), and tubular epithelial degeneration (p < 0.05). L-carnitine and amifostine were similar in protective effect. Conclusion: L-carnitine was equally effective as amifostine in protecting the kidney against acute irradiation damage.
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نویسندگان مقاله v yurut caloglu | v yurut caloglu
trakya university, faculty of medicine, departments of radiation oncology, edirne, turkey


m caloglu | m. caloglu
trakya university, faculty of medicine, departments of radiation oncology, edirne, turkey


t دنیز yalta | t deniz yalta
trakya university, faculty of medicine, departments of pathology, edirne, turkey


t aktoz | t. aktoz
trakya university, faculty of medicine, departments of urology, edirne, turkey


d nurlu | d. nurlu
trakya university, faculty of medicine, departments of radiation oncology, edirne, turkey


n kilic durankus | n kilic durankus
trakya university, faculty of medicine, departments of radiation oncology, edirne, turkey


e اردا | e. arda
trakya university, faculty of medicine, departments of urology, edirne, turkey


g turkkan | g. turkkan
trakya university, faculty of medicine, departments of radiation oncology, edirne, turkey


o inci | o. inci
trakya university, faculty of medicine, departments of urology, edirne, turkey
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-578&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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