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International Journal of Radiation Research، جلد ۱۳، شماره ۳، صفحات ۲۳۵-۲۴۱
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عنوان انگلیسی Development of methemoglobin-based biological dosimetry in gamma–irradiated mice
چکیده انگلیسی مقاله Background: A new biological dosimeter based on methemoglobin level was developed in this study. Materials and Methods: Methemoglobin level in erythrocytes from mice subjected to &gamma rays from a 60Co source was detected using the methemoglobin kit. The dose range was from 0.5 to 8 Gy and the dose rate was 0.5 Gy/min. Results: The results demonstrate that methemoglobin level increases with increasing dose. The detection limit based on methemoglobin has a lower limit of dose estimation of about 1 Gy. The high levels of methemoglobin are maintained for at least 28 days, and the maximal increase of methemoglobin observed occurs at about 30 min after &gamma irradiation. The relationship between dosage and the increased methemoglobin level can be expressed by a linear quadratic equation of y = -8.75 x2 + 168.09 x + 32.66, with the correlation coefficient, r, equal to 0.96. The best suggested time for blood collection is up to 1 day after &gamma irradiation. The doses absorbed by mice as estimated from the use of the dose-response relationship were close to the blind doses of 1, 2, 4 and 8 Gy. Conclusion: Methemoglobin is a quick, simple, and precise biomarker for the early assessment of the absorbed dose in mice.
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نویسندگان مقاله x h زانگ | x h zhang
department of nuclear science and engineering, nanjing university of aeronautics and astronautics, nanjing, jiangsu, p.r. china


y n زانگ | y n zhang
department of nuclear science and engineering, nanjing university of aeronautics and astronautics, nanjing, jiangsu, p.r. china


x y امین | x y min
department of nuclear science and engineering, nanjing university of aeronautics and astronautics, nanjing, jiangsu, p.r. china


z c lou | z c lou
department of nuclear science and engineering, nanjing university of aeronautics and astronautics, nanjing, jiangsu, p.r. china


علیرضا ونگ | a l wang
the first affiliated hospital of bengbu medical college, bengbu medical college, bengbu, anhui, p.r. china


x d hu | x d hu
department of nuclear science and engineering, nanjing university of aeronautics and astronautics, nanjing, jiangsu, p.r. china


h q زانگ | h q zhang
department of nuclear science and engineering, nanjing university of aeronautics and astronautics, nanjing, jiangsu, p.r. china
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-567&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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