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International Journal of Radiation Research، جلد ۱۳، شماره ۳، صفحات ۲۵۱-۲۵۷
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عنوان انگلیسی Trabecular bone changes induced by fast neutrons versus gamma rays in mice
چکیده انگلیسی مقاله Background: The trabecular bone changes in the tibia of C3H/HeN mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 Gy) or 137Cs-generated gamma-rays (0-6 Gy). Materials and Methods: Serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. Tibiae were analyzed using microcomputed tomography. Biomechanical property and osteoclast surface level were measured. Results: There was a significant relationship between the loss of bone architecture and the radiation dose, and the best-fitting dose-response curves were linear-quadratic. Mean relative biological effectiveness (RBE) values (Ref. gamma) of 2.05 and 2.33 were estimated for fast neutron irradiation in trabecular bone volume fraction and bone mineral density, respectively. There was a substantial reduction in osteoclast surface level in tartrate-resistant acid phosphatase-stained histological sections of tibial metaphyses in irradiated mice with high dose of neutrons. Conclusion: There was a significant relationship between the loss of bone architecture and the radiation dose. The difference of osteoclastic bone resorption may represent a contributor to the low RBE in high dose of irradiation level relative to that of low dose level.
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نویسندگان مقاله y یانگ | y. yang
college of veterinary medicine, chonnam national university, gwangju, republic of korea


هری lee | h j lee
korea institute of radiological amp;amp; medical science, seoul, republic of korea


h جنگ | h. jang
college of veterinary medicine, chonnam national university, gwangju, republic of korea


ژاک اچ lee | j h lee
ministry of food and drug safety, osong, republic of korea


c مون | c. moon
college of veterinary medicine, chonnam national university, gwangju, republic of korea


j c کیم | j c kim
college of veterinary medicine, chonnam national university, gwangju, republic of korea


u jung | u. jung
advanced radiation technology institute, kaeri, jeongeup, republic of korea


سید کاظم jo | s k jo
advanced radiation technology institute, kaeri, jeongeup, republic of korea


c m کانگ | c m kang
korea institute of radiological amp;amp; medical science, seoul, republic of korea


سید حسین کیم | s h kim
college of veterinary medicine, chonnam national university, gwangju, republic of korea
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-569&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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