این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Radiation Research، جلد ۱۳، شماره ۲، صفحات ۱۵۷-۱۶۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Spatial memory and changes in expression of genes of neurotrophic factors in adult rat brain after fractionated whole brain irradiation
چکیده انگلیسی مقاله Background: Ionizing radiation causes cognitive impairment in adult brain. However, the effects of various irradiation protocols with fractionated fixed total dose on hippocampal function have not yet been studied. Materials and Methods: Fractionated whole brain irradiation with a total dose of 36 Gy was performed according to the following protocols: 2Gy-18 fractions (2Gy*18), 4Gy-9 fraction (4Gy*9) and 6Gy-6 fractions (6Gy*6). Changes in spatial memory were studied in Morris water maze tests at 12th and 17th day after irradiation with a hidden platform and at 38th day after irradiation without a platform. Levels of expression of brain derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) genes were evaluated using qPCR. Results: Expression of genes of neurotrophic factors (BDNF and VEGF) was decreased at 4th and 8th week after irradiation, the decrease depended on fractionation. The Morris water maze test with a hidden platform showed improvement in long-term spatial memory at 12th and 17th day after irradiation. In the Morris water maze test without platform cognitive deficit was detected only in 6Gy*6 group at 4th week after irradiation. Conclusion: Our study shows that different fractionation protocols affect hippocampal functions differently, and that the greatest negative impact has the protocol with the maximum single dose. In addition, decrease in expression of genes of neurotrophic factors might play an important role in cognitive impairment.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله یارعلی zorkina | y a zorkina
vp serbsky national research center for social and forensic psychiatry, department of basic and applied neurobiology, kropotkinskiy side street 23, 119034, moscow, russian federation


عزت الله zubkov | e a zubkov
vp serbsky national research center for social and forensic psychiatry, department of basic and applied neurobiology, kropotkinskiy side street 23, 119034, moscow, russian federation


z i storozheva | z i storozheva
vp serbsky national research center for social and forensic psychiatry, department of basic and applied neurobiology, kropotkinskiy side street 23, 119034, moscow, russian federation


g e gorlachev | g e gorlachev
burdenko neurosurgery institute rams, department of radiology and radiosurgery, 4th tverskaya-yamskaya st. 16, 125047, moscow, russian federation


عبدالوهاب golanov | a v golanov
burdenko neurosurgery institute rams, department of radiology and radiosurgery, 4th tverskaya-yamskaya st. 16, 125047, moscow, russian federation


v p chekhonin | v p chekhonin
vp serbsky national research center for social and forensic psychiatry, department of basic and applied neurobiology, kropotkinskiy side street 23, 119034, moscow, russian federation
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-554&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات