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International Journal of Radiation Research، جلد ۱۳، شماره ۲، صفحات ۱۷۳-۱۸۰
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عنوان انگلیسی Determination of human absorbed dose from [153Sm]-Samarium maltolate based on distribution data in rats
چکیده انگلیسی مقاله Background: Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. Due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153Sm]-samarium maltolate was developed for possible therapeutic applications. Materials and Methods: The organ radiation-absorbed doses have been evaluated for human based on animal data. After intravenous administration of 153Sm-Mal to four groups of rats, they were sacrificed at exact time intervals and the percentage of injected dose per gram of each organ was calculated by direct counting from rat data. Then S values for 153Sm by using specific absorbed fractions were calculated. By taking advantage of the formulation that Medical Internal Radiation Dose suggests, radiation-absorbed doses for all organs were calculated and extrapolated from rat to human. Results: From rat data, it is estimated that a 185-MBq injection of 153Sm-Mal into a human might result in the highest absorbed dose in the lymphoma tissues (liver 176.3, lungs 68, spleen 66.8 and sternum 19 mGy), especially in liver respect to the other tissues. Conclusion: These results suggest 153Sm-Mal as an efficiently new therapeutic agent in order to overcome possible lymphatic malignancies.
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نویسندگان مقاله h rezaeejam | h. rezaeejam
department of medical physics and biomedical engineering, faculty of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a حکیمی | a. hakimi
department of energy engineering and physics, amir kabir university of technology, tehran, iran


علیرضا جلیلیان | a r jalilian
nuclear science and technology research institute, tehran, iran


p عباسیان | p. abbasian
department of energy engineering and physics, amir kabir university of technology, tehran, iran


s شیروانی آران | s shirvani aran
nuclear science and technology research institute, tehran, iran


m قنادی مراغه | m ghannadi maragheh
nuclear science and technology research institute, tehran, iran
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-557&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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