این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Radiation Research، جلد ۱۲، شماره ۳، صفحات ۲۲۹-۲۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective effect of vitamin D on radiation-induced lung injury: Experimental evidence
چکیده انگلیسی مقاله Background: Vitamin D, especially its most active metabolite 1,25-dihydroxyvitamin D₃(Vit D) is essential in regulating a wide variety of biologic processes, such as regulating mesangial cell activation. The objective of this study was to assess the histopathological changes of effectiveness of Vit D as a protective agent against radiation induced lung injury. Materials and Methods: Eighteen Wistar rats were divided into three groups: control group (group 1:4 rats), irradiation alone group (group 2:7 rats) and irradiation+vit D (group 3:7 rats). Rats in group 2 and 3 were exposed to 20 Gy radiations to the right lung in a Co60 radiotherapy machine under general anesthesia. Additionally, rats in group 3 received Vit D at a single dose of 0.2 mcg injected IM 2 hours before exposure to irradiation. Rats were sacrificed and lungs were dissected fifty days after post-irradiation. Myofibroblasts and vitamin D₃receptors (VDR) in extracted lungs were stained by immunohistochemistry using alpha-smooth muscle actin (SMA) and VDR antibodies. Blinded histological evaluation was performed to assess lung injury. Lung injury was assessed by the acute lung injury score and myofibroblastic differentiation score. Results: Acute lung injury scores and myofibroblastic differentiation scores were significantly lower in the radiation+vit D group compared to irradiation alone group (p=0.001 and p=0.001, respectively). Conclusion: This study indicates that administration of vit D plays a protective role against acute lung injury through blocking myofibroblastic differentiation.
کلیدواژه‌های انگلیسی مقاله Radiation, lung injury, vitamin D, VDR, calcitriol, fibrosis
نویسندگان مقاله f bir | f. bir
pamukkale university, faculty of medicine, department of pathology, denizli, turkey


b baltalarlı | b baltalarlı
pamukkale university, faculty of medicine, department of radiation oncology, denizli, turkey


g abban | g. abban
pamukkale university, faculty of medicine, department of histology, denizli, turkey


n demirkan | n. demirkan
pamukkale university, faculty of medicine, department of pathology, denizli, turkey
نشانی اینترنتی http://www.ijrr.com/browse.php?a_code=A-10-1-510&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات